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XRCC3 THR241MET polymorphism influence on nuclear buds frequency in exposed to formaldehyde

2011-09Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorGomes, M. G.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2011-11-21T23:06:59Z
dc.date.available2011-11-21T23:06:59Z
dc.date.issued2011-09
dc.description.abstractFormaldehyde (FA), also known as formalin, formal and methyl aldehydes, is a colorless, flammable, strong-smelling gas. It has an important application in embalming tissues and that result in exposures for workers in the pathology anatomy laboratories and mortuaries. Occupational exposure to FA has been shown to induce nasopharyngeal cancer and has been classified as carcinogenic to humans (group 1) on the basis of sufficient evidence in humans and sufficient evidence in experimental animals. Manifold in vitro studies clearly indicated that FA is genotoxic. FA induced various genotoxic effects in proliferating cultured mammalian cells. The cytokinesis-block micronucleus (CBMN) assay was originally developped as an ideal system form easuring micronucleus (MN), however it can also be used to measure nucleoplasmic bridges (NBP) and nuclear buds (NBUD). Over the past decade another unique mechanism of micronucleus formation, known as nuclear budding has emerged. NBUDS is considered as a marker of gene amplification and/or altered gene dosage because the nuclear budding process is the mechanism by which cells removed amplified and/excess DNA.por
dc.identifier.citationLadeira C, Gomes MG, Brito M. XRCC3 THR241MET polymorphism influence on nuclear buds frequency in exposed to formaldehyde. In The European Environmental Mutagens Society, Oslo (Norway), 15th to 18th September 2011. Poster.por
dc.identifier.urihttp://hdl.handle.net/10400.21/457
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectAnatomia patológicapor
dc.subjectMeio laboratorialpor
dc.subjectSaúde ocupacionalpor
dc.subjectFormaldeídopor
dc.titleXRCC3 THR241MET polymorphism influence on nuclear buds frequency in exposed to formaldehydepor
dc.typeconference object
dspace.entity.typePublication
person.familyNameLadeira
person.familyNameBrito
person.givenNameCarina
person.givenNameMiguel
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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