Assessing T-lymphocyte activation by non-conventional metabolomics

Ramalhete, Luís; Calado, Cecília; Sancho, M. Rosário

http://hdl.handle.net/10400.21/14412

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Authors

Ramalhete, Luís

Calado, Cecília

Sancho, M. Rosário

Abstract(s)

The current methodologies to evaluate T-cell function are based on very laborious or/and expensive methods. Nevertheless, the assessment of the appropriate functioning of these cells is very important in the clinical context, namely as a diagnostic tool of T-cell alloreactivity in different hematological settings, solid organ transplantation and immunosuppressive therapy. In the present work, we evaluated the potential of Non-conventional Metabolomics (NM) based on FTIR spectroscopy, in the assessment of T lymphocyte function after mitogen activation by phytohemagglutinin (PHa).

Keywords

Non-conventional Metabolomics (NM) FTIR spectroscopy T lymphocyte Phytohemagglutinin (PHa)

URI

http://hdl.handle.net/10400.21/14412

Citation

RAMALHETE, Luís; CALADO, Cecília R. C.; SANCHO, M. Rosário – Assessing T-lymphocyte activation by non-conventional metabolomics. 33rd European Immunogenetics and Histocompatibility Conference. European Federation of Immunogenetics, 8-11 May, 2019, Lisbon, Portugal. HLA Immune Response Genetics 2019, 93(5):283.