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HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium

2022-08Journal article Open access
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dc.contributor.authorTavares, Ana
dc.contributor.authorAimonen, Kukka
dc.contributor.authorNdaw, Sophie
dc.contributor.authorFučić, Aleksandra
dc.contributor.authorCatalán, Julia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorGomes, Bruno C.
dc.contributor.authorJanasik, Beata
dc.contributor.authorLadeira, Carina
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNamorado, Sónia
dc.contributor.authorNieuwenhuyse, An Van
dc.contributor.authorNorppa, Hannu
dc.contributor.authorScheepers, Paul T. J.
dc.contributor.authorVentura, Célia
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorSantonen, Tiina
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-08-23T09:50:17Z
dc.date.available2022-08-23T09:50:17Z
dc.date.issued2022-08
dc.descriptionEuropean Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733032).pt_PT
dc.description.abstractA study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within a company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTavares A, Aimonen K, Ndaw S, Fučić A, Catalán J, Ladeira C, et al. HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium. Toxics. 2022;10(8):483.pt_PT
dc.identifier.doi10.3390/toxics10080483pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14925
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733032)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/483pt_PT
dc.subjectEffect biomarkerspt_PT
dc.subjectMicronucleipt_PT
dc.subjectComet assaypt_PT
dc.subjectMDApt_PT
dc.subject8-OHdGpt_PT
dc.subjectChromatept_PT
dc.subjectOccupational exposurept_PT
dc.subjectBiomonitoringpt_PT
dc.subjectHBM4EUpt_PT
dc.titleHBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage483pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
person.familyNameLadeira
person.familyNameViegas
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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