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Authors
Advisor(s)
Abstract(s)
O cancro da próstata (CP) é a segunda neoplasia maligna mais comum no homem mundialmente, com incidência de 1.4 milhões e 375 mil mortes anual, segundo a Internacional Agency for Research on Cancer. O objetivo principal deste trabalho é avaliar a eficiência da multimodalidade de imagem PET/RM e PET/TC no cancro da próstata. Metodologia: esta revisão sistemática de literatura foi conduzida de acordo com as orientações do protocolo Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) 2020. A metodologia utilizada para responder as nossas questões de investigação foi Population, Intervention, Comparator and Outcome (PICO). A pesquisa foi realizada nas bases de dados Medline/PubMed, Scopus e Clarivate usando os marcadores boleanos AND e OR. Para o estudo da qualidade metodológica foi utilizado a escala Physiotherapy Evidence Database (PEDro). Resultados: A PET é uma técnica promissora no CP, especialmente no diagnóstico, recidiva e deteção de metástases. Uma das vantagens da utilização de PET/RM em relação ao PET/TC é a menor exposição dos doentes às radiações ionizantes, defeitos de co-registo de imagem e mais vantajosa no planeamento em radioterapia. Discussão: Imagens híbridas fornecem informações indispensáveis na decisão terapêutica, principalmente na prostatectomia radical (PR), em que é muito importante estabelecer um equilíbrio entre o controle tumoral e a preservação da função sexual e urinária. Conclusão: Imagens híbridas, de preferência PET/RM, devem ser inclusas na avaliação de CP primário, recidivas bioquímicas e avaliação de invasão ganglionar devido à elevada resolução espacial e combinação de resultados morfológicos e funcionais.
ABSTRACT - Prostate cancer (PC) is the second most common malignant neoplasm in men worldwide, with an incidence of 1.4 million and 375,000 deaths annually, according to the International Agency for Research on Cancer. The main objective of this paper is to evaluate the efficiency of multimodality PET/MRI and PET/CT imaging in prostate cancer. Methodology: This systematic literature review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 protocol. The methodology used to answer our research questions was Population, Intervention, Comparator, and Outcome (PICO). The search was conducted in Medline/PubMed, Scopus, and Clarivate databases using the Boolean markers AND and OR. The Physiotherapy Evidence Database (PEDro) scale was used to study methodological quality. Results: PET is a promising technique in PC, especially in diagnosis, recurrence, and metastasis. One of the advantages of using PET/MRI compared to PET/CT is less exposure of patients to ionizing radiation, imaging co-registration defects, and more advantageous in planning in radiotherapy. Discussion: Hybrid imaging provides indispensable information in the therapeutic decision, especially in radical prostatectomy (RP), in which it is very important to establish a balance between tumor control and preservation of sexual and urinary function. Conclusion: Hybrid images, preferably PET/MRI, should be included in the evaluation of primary PC, biochemical recurrences, and evaluation of ganglionic invasion due to the high spatial resolution and combination of morphological and functional results.
ABSTRACT - Prostate cancer (PC) is the second most common malignant neoplasm in men worldwide, with an incidence of 1.4 million and 375,000 deaths annually, according to the International Agency for Research on Cancer. The main objective of this paper is to evaluate the efficiency of multimodality PET/MRI and PET/CT imaging in prostate cancer. Methodology: This systematic literature review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 protocol. The methodology used to answer our research questions was Population, Intervention, Comparator, and Outcome (PICO). The search was conducted in Medline/PubMed, Scopus, and Clarivate databases using the Boolean markers AND and OR. The Physiotherapy Evidence Database (PEDro) scale was used to study methodological quality. Results: PET is a promising technique in PC, especially in diagnosis, recurrence, and metastasis. One of the advantages of using PET/MRI compared to PET/CT is less exposure of patients to ionizing radiation, imaging co-registration defects, and more advantageous in planning in radiotherapy. Discussion: Hybrid imaging provides indispensable information in the therapeutic decision, especially in radical prostatectomy (RP), in which it is very important to establish a balance between tumor control and preservation of sexual and urinary function. Conclusion: Hybrid images, preferably PET/MRI, should be included in the evaluation of primary PC, biochemical recurrences, and evaluation of ganglionic invasion due to the high spatial resolution and combination of morphological and functional results.
Description
Mestrado em Radiações Aplicadas às Tecnologias da Saúde - Área de especialização: Ressonância Magnética
Keywords
Medicina nuclear Cancro da próstata PET MRI CT Nuclear medicine Prostate cancer
Citation
Varela LP. PET/MRI/CT no diagnóstico do cancro da próstata: revisão sistemática [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2023.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa