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Lack of consistent association between asthma, allergic diseases, and intestinal helminth infection in school-aged children in the Province of Bengo, Angola

2021-06Journal article Open access
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dc.contributor.authorArrais, Margarete
dc.contributor.authorLulua, Ofélia
dc.contributor.authorQuifica, Francisca
dc.contributor.authorRosado-Pinto, José
dc.contributor.authorGama, Jorge M.
dc.contributor.authorCooper, Philip J.
dc.contributor.authorTaborda-Barata, Luis
dc.contributor.authorBrito, Miguel
dc.date.accessioned2021-06-12T17:19:18Z
dc.date.available2021-06-12T17:19:18Z
dc.date.issued2021-06
dc.description.abstractEpidemiological studies have shown conflicting findings on the relationship between asthma, atopy, and intestinal helminth infections. There are no such studies from Angola; therefore, we aimed to evaluate the relationship between asthma, allergic diseases, atopy, and intestinal helminth infection in Angolan schoolchildren. We performed a cross-sectional study of schoolchildren between September and November 2017. Five schools (three urban, two rural) were randomly selected. Asthma, rhinoconjunctivitis, and eczema were defined by appropriate symptoms in the previous 12 months: atopy was defined by positive skin prick tests (SPT) or aeroallergen-specific IgE; intestinal helminths were detected by fecal sample microscopy. In total, 1023 children were evaluated (48.4% female; 57.6% aged 10–14 years; 60.5% urban). Asthma, rhinoconjunctivitis, or eczema were present in 9%, 6%, and 16% of the studied children, respectively. Only 8% of children had positive SPT, but 64% had positive sIgE. Additionally, 40% were infected with any intestinal helminth (A. lumbricoides 25.9%, T. trichiura 7.6%, and H. nana 6.3%). There were no consistent associations between intestinal helminth infections and asthma, allergic diseases, or atopy, except for A. lumbricoides, which was inversely associated with rhinoconjunctivitis and directly associated with aeroallergen-specific IgE. We concluded that, overall, intestinal helminth infections were not consistently associated with allergic symptoms or atopy. Future, preferably longitudinal, studies should collect more detailed information on helminth infections as part of clusters of environmental determinants of allergies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArrais M, Lulua O, Quifica F, Rosado-Pinto J, Gama JM, Brito M, et al. Lack of consistent association between asthma, allergic diseases, and intestinal helminth infection in school-aged children in the Province of Bengo, Angola. Int J Environ Res Public Health. 2021;18(11):6156.pt_PT
dc.identifier.doi10.3390/ijerph18116156pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13434
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/11/6156pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAllergic diseasept_PT
dc.subjectIntestinal helminth infectionpt_PT
dc.subjectAsthmapt_PT
dc.subjectAtopypt_PT
dc.subjectEczemapt_PT
dc.subjectHelminthspt_PT
dc.subjectRhinoconjunctivitispt_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleLack of consistent association between asthma, allergic diseases, and intestinal helminth infection in school-aged children in the Province of Bengo, Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage6156pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume18pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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