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Hemin reduces inflammation associated with TNBS-induced colitis

2018-09Artigo científico Acesso aberto
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dc.contributor.authorMateus, Vanessa
dc.contributor.authorRocha, João
dc.contributor.authorMota-Filipe, Helder
dc.contributor.authorSepodes, Bruno
dc.contributor.authorPinto, Rui
dc.date.accessioned2018-12-29T20:04:36Z
dc.date.available2018-12-29T20:04:36Z
dc.date.issued2018-09
dc.description.abstractPurpose - Hemin is a heme-oxygenase inducer, which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects. These properties are beneficial therapeutical effects to inflammatory bowel disease (IBD). IBD is a worldwide health problem characterized by chronic inflammation of intestinal epithelium, which promotes intestinal and extraintestinal symptomatology. Current treatment only induces and maintains the patient in remission and results in many side effects. The research of other pharmacologic approaches is crucial to the treatment of IBD. The aim of this study is to evaluate the effect of hemin in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Materials and methods - Male CD-1 mice with TNBS-induced colitis were treated with a daily dose of hemin 5 mg/kg body weight/day and 10 mg/kg body weight/day intraperitoneal, during 4 days. The evaluated parameters were fecal hemoglobin, alkaline phosphatase (ALP), myeloperoxidase, tumor necrosis factor-α, interleukin (IL)-1β, IL-10, histopathologic analysis, urea, creatinine, and alanine aminotransferase. Results - The hemin-treated mice presented a decrease in fecal hemoglobin, ALP, and proinflammatory cytokine concentrations compared to the TNBS group. Histopathology analysis confirmed the decrease in lesion extension produced by hemin. Conclusion - These findings suggest that hemin treatment reduces hemorrhagic focus, intestinal damage, tissue inflammation, and lesion extension associated with experimental colitis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMateus V, Rocha J, Mota-Filipe H, Sepodes B, Pinto R. Hemin reduces inflammation associated with TNBS-induced colitis. Clin Exp Gastroenterol. 2018;11:325-34.pt_PT
dc.identifier.doi10.2147/CEG.S166197pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/9220
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/hemin-reduces-inflammation-associated-with-tnbs-induced-colitis-peer-reviewed-article-CEG#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectExperimental colitispt_PT
dc.subjectAnti-inflammatory effectpt_PT
dc.subjectHeme-oxygenase inducerpt_PT
dc.titleHemin reduces inflammation associated with TNBS-induced colitispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage334pt_PT
oaire.citation.startPage325pt_PT
oaire.citation.titleClinical and Experimental Gastroenterologypt_PT
oaire.citation.volume11pt_PT
person.familyNamePinho Mateus
person.givenNameVanessa Alexandra
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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