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Advisor(s)
Abstract(s)
Cerca de 5% da população mundial é portadora de genes responsáveis por hemoglobinopatias, e a cada ano, aproximadamente 200 mil crianças africanas nascem com um dos tipos de hemoglobinopatia. As hemoglobinopatias resultam de mutações que levam à diminuição ou modificação das hemoglobinas, que são estruturalmente normais. As mais comuns incluem as síndromes talassémicas e a anemia falciforme. Apesar de ser considerado um problema de saúde pública, Cabo Verde ainda não possui um sistema de diagnóstico de hemoglobinopatias bem estabelecido, nem estudos que permitam determinar a prevalência dessas condições na população. O objetivo primordial deste projeto é a implementação de um laboratório de rastreio de hemoglobinopatias em Cabo Verde, com foco especial na anemia falciforme. Este laboratório desempenhará um papel crucial na planificação de programas destinados a determinar a prevalência das hemoglobinopatias na população das ilhas de Cabo Verde. Além disso, servirá como suporte ao Ministério da Saúde, auxiliando na formulação de novas estratégias para o diagnóstico precoce e tratamento adequado de indivíduos afetados por hemoglobinopatias. O processo de planeamento para estabelecer um laboratório de despiste de hemoglobinopatias abrange as melhores práticas de gestão e administração clínico-laboratorial. A primeira etapa envolve a elaboração de um plano de atividades abrangente, incluindo os seguintes elementos: localização, missão, visão e valores do laboratório, descrição detalhada do estabelecimento, obtenção de alvarás e licenças de acordo com a legislação cabo-verdiana, técnicas a serem desenvolvidas, análise económica, estratégias de marketing e um plano de análise SWOT para avaliar forças, fraquezas, oportunidades e ameaças associadas ao projeto. Esta iniciativa representa um passo significativo para melhorar a saúde pública em Cabo Verde, fornecendo diagnósticos precisos e promovendo o tratamento adequado das hemoglobinopatias, especialmente a anemia falciforme, que afeta a qualidade de vida de muitos cabo-verdianos. O laboratório de rastreio de hemoglobinopatias desempenhará um papel vital na redução da incidência e no fornecimento de cuidados médicos mais eficazes para aqueles que necessitam. Estabelecendo inicialmente uma população alvo, por exemplo crianças, gravidas, adolescentes.
ABSTRACT - About 5% of the world's population carries genes responsible for hemoglobinopathies, and each year, approximately 200,000 African children are born with one of the types of hemoglobinopathy. Hemoglobinopathies result from mutations that lead to a decrease or modification of structurally normal hemoglobins. The most common include thalassemic syndromes and sickle cell anemia. Despite being considered a public health problem, Cape Verde does not yet have a well-established system for diagnosing hemoglobinopathies, nor studies that allow determining the prevalence of these conditions in the population. The primary objective of this project is the implementation of a hemoglobinopathies screening laboratory in Cape Verde, with a special focus on sickle cell anemia. This laboratory will play a crucial role in planning programs aimed at determining the prevalence of hemoglobinopathies in the population of the Cape Verde Islands. Furthermore, it will serve as support to the Ministry of Health, helping to formulate new strategies for early diagnosis and adequate treatment of individuals affected by hemoglobinopathies. The planning process to establish a hemoglobinopathies reference laboratory encompasses best practices in clinical laboratory management and administration. The first step involves the preparation of a comprehensive activity plan, including the following elements: location, mission, vision, and values of the laboratory, detailed description of the establishment, obtaining permits and licenses following Cape Verdean legislation, techniques to be developed, economic analysis, marketing strategies and a SWOT analysis plan to evaluate strengths, weaknesses, opportunities, and threats associated with the project. This initiative represents a significant step towards improving public health in Cape Verde, providing accurate diagnoses, and promoting adequate treatment of hemoglobinopathies, especially sickle cell anemia, which affects the quality of life of many Cape Verdeans. The hemoglobinopathies screening laboratory will play a vital role in reducing the incidence and providing more effective medical care to those who need it. Initially establishing a target population, e.g. children, pregnant women, adolescents.
ABSTRACT - About 5% of the world's population carries genes responsible for hemoglobinopathies, and each year, approximately 200,000 African children are born with one of the types of hemoglobinopathy. Hemoglobinopathies result from mutations that lead to a decrease or modification of structurally normal hemoglobins. The most common include thalassemic syndromes and sickle cell anemia. Despite being considered a public health problem, Cape Verde does not yet have a well-established system for diagnosing hemoglobinopathies, nor studies that allow determining the prevalence of these conditions in the population. The primary objective of this project is the implementation of a hemoglobinopathies screening laboratory in Cape Verde, with a special focus on sickle cell anemia. This laboratory will play a crucial role in planning programs aimed at determining the prevalence of hemoglobinopathies in the population of the Cape Verde Islands. Furthermore, it will serve as support to the Ministry of Health, helping to formulate new strategies for early diagnosis and adequate treatment of individuals affected by hemoglobinopathies. The planning process to establish a hemoglobinopathies reference laboratory encompasses best practices in clinical laboratory management and administration. The first step involves the preparation of a comprehensive activity plan, including the following elements: location, mission, vision, and values of the laboratory, detailed description of the establishment, obtaining permits and licenses following Cape Verdean legislation, techniques to be developed, economic analysis, marketing strategies and a SWOT analysis plan to evaluate strengths, weaknesses, opportunities, and threats associated with the project. This initiative represents a significant step towards improving public health in Cape Verde, providing accurate diagnoses, and promoting adequate treatment of hemoglobinopathies, especially sickle cell anemia, which affects the quality of life of many Cape Verdeans. The hemoglobinopathies screening laboratory will play a vital role in reducing the incidence and providing more effective medical care to those who need it. Initially establishing a target population, e.g. children, pregnant women, adolescents.
Description
Mestrado em Tecnologias Clínico-Laboratoriais
Keywords
Hemoglobinopatias Anemia falciforme Diagnóstico Meio laboratorial Cabo Verde Hemoglobinopathies Sickle cell anemia Diagnosis Laboratory Cape Verde MTCL
Citation
Luz SC. Implementação de um laboratório de pesquisa de hemoglobinopatias em Cabo Verde [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2024.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa