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Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect

2024-02Journal article Open access
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dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorVeiga, Luisa
dc.contributor.authorGinete, Catarina
dc.contributor.authorSantos, Brígida
dc.contributor.authorMiranda, Armandina
dc.contributor.authorVasconcelos, Jocelyne Neto de
dc.contributor.authorBrito, Miguel
dc.date.accessioned2024-01-09T15:58:09Z
dc.date.available2024-01-09T15:58:09Z
dc.date.issued2024-02
dc.descriptionIPL/2020/SCDVOCbiom_ESTeSL/IPL. UI/BD/150705/2020/FCT.pt_PT
dc.description.abstractSickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and even the adhesion properties to endothelial cells of SCA subjects. Due to VOC episodes, these patients are also more susceptible to recurrent bacterial translocation and dysbiosis. Given this, our study aimed to uncover the interplay between adhesion molecules, gut microbiome, and hydroxyurea in a population of Angolan SCA children. Serum and fecal samples were obtained before and after HU treatment in 35 children. After HU, four of these adhesion molecules were significantly reduced: sE-selectin (p = 0.002), ADAMTS13 (p = 0.023), sICAM-1 (p = 0.003), and sVCAM-1 (p = 0.018). A positive correlation was observed between the number of neutrophils and sICAM-1, platelets, and sP-selectin, and also between leukocytes, sICAM-1, and sVCAM-1. Most taxa showing a significant correlation mainly belonged to the Clostridiales order. Specifically, from the Clostridium genera, the groups g19, g21, and g34 were all negatively correlated with HbF levels; g19, g21, and g24 positively correlated with leukocytes; g19 positively with neutrophils and sVCAM-1; and g34 positively with E- and P-selectin. Serratia, an opportunistic pathogen, was positively correlated with sE-selectin and sICAM-1 levels. Additionally, a negative correlation was observed between sP-selectin and Bifidobacterium. Research studies in this area could improve our understanding and contribute to finding new prognostic biomarkers to guarantee precise SCA patient stratification and predict severe complications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgadinho M, Veiga L, Ginete C, Santos B, Miranda A, Brito M, et al. Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect. Ann Hematol. 2024;103(2):409-19.pt_PT
dc.identifier.doi10.1007/s00277-023-05589-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16827
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00277-023-05589-5pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell anemiapt_PT
dc.subjectAdhesion moleculespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectHydroxyureapt_PT
dc.subjectMicrobiomept_PT
dc.subjectIPL/2020/SCDVOCbiom_ESTeSL/IPLpt_PT
dc.subjectUI/BD/150705/2020/FCTpt_PT
dc.titleDifferential expression of adhesion molecules in sickle cell anemia and gut microbiome effectpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage419pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage409pt_PT
oaire.citation.titleAnnals of Hematologypt_PT
oaire.citation.volume103pt_PT
person.familyNameNeves Delgadinho
person.familyNameVeiga
person.familyNameHonrado Ginete
person.familyNameBrito
person.givenNameMariana Isabel
person.givenNameLuisa
person.givenNameAna Catarina
person.givenNameMiguel
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0003-1153-8343
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridL-2730-2013
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id8318978600
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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