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Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration

2025-01Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCosta, Inês
dc.contributor.authorCarvalho, Ana
dc.contributor.authorAndrade, Helton
dc.contributor.authorPereira, Bruno
dc.contributor.authorCamacho, Pedro
dc.date.accessioned2025-02-20T11:48:57Z
dc.date.available2025-02-20T11:48:57Z
dc.date.issued2025-01
dc.description.abstractAim: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. Methods: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 participants were included from the Instituto de Retina de Lisboa (IRL) study (IPL/2022/MetAllAMD_ESTeSL) and divided into 4 groups according to the Rotterdam classification for AMD. Spectral-domain optical coherence tomography (SD-OCT) was used to assess and quantify GCC and choroid thickness at two-time points (first visit vs last visit) with a minimum interval of 3y. Results: In the GCC inner ring, a thinner thickness (P=0.001) was observed in the atrophic AMD group (51.3±21.4 µm) compared to the early AMD (84.3±11.5 µm), intermediate AMD (77.6±16.1 µm) and neovascular AMD (88.9±16.3 µm) groups. Choroidal thickness quantification showed a generalized reduction in the central circle (P=0.002) and inner ring (P=0.001). Slight reductions in retinal thickness were more accentuated in the inner ring in the atrophic AMD (-13%; P<0.01). Conclusion: The variation of the analyzed structures could be an indicator of the risk of progression with neurodegenerative (GCC) or vascular (choroid) patterns in the intermediate and atrophic AMD. The quantification of both structures can provide important information about the risk of disease progression in the early and intermediate stages but also for the evolution pattern into late stages (atrophic or neovascular).eng
dc.description.sponsorshipSupported by FCT/MCTES UIDB/05608/2020, and UIDP/05608/2020, IDI&CA grant IPL/2022/MetAllAMD_ESTeSL by H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, and by Retina Institute of Lisbon (IRL).
dc.identifier.citationCosta I, Carvalho A, Andrade H, Pereira B, Camacho P. Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration. Int J Ophthalmol. 2025;18(1):103-10.
dc.identifier.doi10.18240/ijo.2025.01.12
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.urihttp://hdl.handle.net/10400.21/21545
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIJO Press
dc.relationIPL/2022/MetAllAMD_ESTeSL
dc.relation.hasversionhttp://ies.ijo.cn/gjyken/article/abstract/20250112
dc.relation.ispartofInternational Journal of Ophthalmology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectOphthalmology
dc.subjectAge-related macular degeneration
dc.subjectGanglion cell complex
dc.subjectGeographic atrophy
dc.subjectChoroidal neovascularization
dc.subjectSpectral domain optical coherence tomography
dc.subjectSD-OCT
dc.subjectFCT_UIDB/05608/2020
dc.subjectFCT_UIDP/05608/2020
dc.subjectIPL/2022/MetAllAMD_ESTeSL
dc.titleNeurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degenerationeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage110
oaire.citation.issue1
oaire.citation.startPage103
oaire.citation.titleInternational Journal of Ophthalmology
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePereira
person.familyNameCamacho
person.givenNameBruno
person.givenNamePedro
person.identifier.ciencia-id271F-B4E1-014E
person.identifier.orcid0000-0001-9269-8335
person.identifier.orcid0000-0002-2986-5652
relation.isAuthorOfPublication2a6ea9cf-68c0-405c-a961-26a3eeb59136
relation.isAuthorOfPublicationc41e9c52-157e-4375-8005-b609cfc374e7
relation.isAuthorOfPublication.latestForDiscovery2a6ea9cf-68c0-405c-a961-26a3eeb59136

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