Repository logo
 
Publication

Risk assessment of combined exposure to multiple chemicals: the case of mycotoxins exposure

2011-06Journal article Open access
Simple item page
dc.contributor.authorViegas, Susana
dc.contributor.authorViegas, Carla
dc.contributor.authorRamos, Carla
dc.contributor.authorSilva, Marina
dc.contributor.authorSabino, Raquel
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorRosado, Laura
dc.date.accessioned2020-03-24T17:34:28Z
dc.date.available2020-03-24T17:34:28Z
dc.date.issued2011-06
dc.description.abstractBackground: It is well established that people are exposed to a diverse and dynamic mixture of chemicals as a routine part of their existence, and there is clear evidence that toxicity can be modified by simultaneous or sequential exposure to multiple chemicals. Nevertheless, risk assessments have focused mainly on exposure to individual chemicals in a specific environment via a single route or pathway. It has repeatedly been demonstrated that Aflatoxin B1 and ochratoxin A belong to the most frequently occurring mycotoxins. However, only just recently, the risk resulting from their simultaneous occurrence could be assessed due to new information about their combined biological effects. Materials and Methods: A descriptive study was developed to monitor air fungal contamination in 10 hospital food units. Five air samples of 250 liters through the impaction method were collected in food storage facilities, kitchen, food plating, canteen and also, outside premises since this was the place regarded as reference. Results and Discussion: Besides other fungal species, in one of the food units, Aspergillus flavus and Aspergillus ochraceus were isolated. After that, weight-of-evidence classification based in the work developed by Mumtaz & Durkin (1992) was applied to qualitative assess the weight of evidence for the interaction between aflatoxin B1 and ochratoxin A and it was possible to conclude that this interaction is likely to have relevance to potential human health effects. Conclusions: Limits for mycotoxins human exposure only consider the effects of each toxin by itself and do not take into consideration their combined effects. It is, therefore, necessary to revise it to permit performing more accurate risk assessments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas S, Viegas C, Ramos C, Almeida M, Sabino R, Veríssimo C, et al. Risk assessment of combined exposure to multiple chemicals: the case of mycotoxins exposure. In: Almeida J, Ferreira A, Paixão S, Pinto MV, Sá NL, Santos C, et al. Congresso Internacional de Saúde Ambiental. Coimbra: Departamento de Saúde Ambiental - Escola Superior de Tecnologia da Saúde de Coimbra; 2011. p. 262-6.pt_PT
dc.identifier.isbn978-989-8252-12-8
dc.identifier.urihttp://hdl.handle.net/10400.21/11325
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectExposure to mixturespt_PT
dc.subjectMycotoxinspt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectWeight-of-evidence classificationpt_PT
dc.subjectToxicological interactionpt_PT
dc.titleRisk assessment of combined exposure to multiple chemicals: the case of mycotoxins exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbrapt_PT
oaire.citation.endPage266pt_PT
oaire.citation.startPage262pt_PT
person.familyNameViegas
person.familyNameViegas
person.givenNameSusana
person.givenNameCarla
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0002-1545-6479
person.identifier.ridI-4053-2012
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id55443609700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Risk assessment of combined exposure to multiple chemicals_the case of mycotoxins exposure.pdf
Size:
8.91 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos