Repository logo
 
Publication

Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)

2022-11Journal article Open access
Simple item page
dc.contributor.authorNobre, José Guilherme
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorSilva, Carina
dc.contributor.authorMendes, Joana
dc.contributor.authorMateus, Vanessa
dc.contributor.authorRibeiro, Edna
dc.contributor.authorCosta, Diogo Alpuim
dc.contributor.authorLopes, Miguel
dc.contributor.authorPedroso, Ana Isabel
dc.contributor.authorTrigueiros, Frederico
dc.contributor.authorRodrigues, Maria Inês
dc.contributor.authorSousa, Cristina Lino de
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-12-14T17:49:56Z
dc.date.available2022-12-14T17:49:56Z
dc.date.issued2022-11
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractBackground: Gut microbiota is intrinsically associated with the immune system and can promote or suppress infectious diseases, especially viral infections. This study aims to characterize and compare the microbiota profile of infected patients with SARS-CoV-2 (milder or more severe symptoms), non-infected people, and recovered patients. This is a national, transversal, observational, multicenter, and case-control study that analyzed the microbiota of COVID-19 patients with mild or severe symptoms at home, at the hospital, or in the intensive care unit, patients already recovered, and healthy volunteers cohabiting with COVID-19 patients. DNA was isolated from stool samples and sequenced in a NGS platform. A demographic questionnaire was also applied. Statistical analysis was performed in SPSS. Results: Firmicutes/Bacteroidetes ratios were found to be significantly lower in infected patients (1.61 and 2.57) compared to healthy volunteers (3.23) and recovered patients (3.89). Furthermore, the microbiota composition differed significantly between healthy volunteers, mild and severe COVID-19 patients, and recovered patients. Furthermore, Escherichia coli, Actinomyces naeslundii, and Dorea longicatena were shown to be more frequent in severe cases. The most common COVID-19 symptoms were linked to certain microbiome groups. Conclusion: We can conclude that microbiota composition is significantly affected by SARS-CoV-2 infection and may be used to predict COVID-19 clinical evolution. Therefore, it will be possible to better allocate healthcare resources and better tackle future pandemics.pt_PT
dc.description.sponsorshipThe authors acknowledge financial support from Instituto Politécnico de Lisboa which supported this project with the grant Microcovid.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNobre JG, Delgadinho M, Silva C, Mendes J, Mateus V, Ribeiro E, Brito M, et al. Gut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study). Front Microbiol. 2022;13:1035422.pt_PT
dc.identifier.doi10.3389/fmicb.2022.1035422pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15150
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmicb.2022.1035422/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectDysbiosispt_PT
dc.subjectMicrobiomept_PT
dc.subjectMicrobiotapt_PT
dc.subjectNext generation sequencingpt_PT
dc.subjectPrognosispt_PT
dc.subjectRisk stratificationpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleGut microbiota profile of COVID-19 patients: prognosis and risk stratification (microCOVID-19 study)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage1035422pt_PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume13pt_PT
person.familyNameNeves Delgadinho
person.familyNameSilva
person.familyNamePinho Mateus
person.familyNameRibeiro
person.familyNameBrito
person.givenNameMariana Isabel
person.givenNameCarina
person.givenNameVanessa Alexandra
person.givenNameEdna
person.givenNameMiguel
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id2411-5936-0820
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0003-1021-7935
person.identifier.orcid0000-0002-3204-3772
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id55258764900
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery81a5cd80-1982-43ba-bde5-4c43ae0e5234

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Gut microbiota profile of COVID-19 patients_prognosis and risk stratification_MicroCOVID-19 study.pdf
Size:
1.06 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos