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Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review

2021-07Journal article Open access
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dc.contributor.authorSilva, Inês
dc.contributor.authorAlípio, Carolina
dc.contributor.authorPinto, Rui
dc.contributor.authorMateus, Vanessa
dc.date.accessioned2021-05-07T15:20:35Z
dc.date.available2021-05-07T15:20:35Z
dc.date.issued2021-07
dc.descriptionProjeto IPL/2020/cEPO_ESTeSLpt_PT
dc.description.abstractErythropoietin (EPO) is a hypoxia-induced hormone produced in adult kidneys with erythropoietic and non-erythropoietic effects. In vivo studies represent an important role to comprehend the efficacy and safety in the early phase of repurposing drugs. The aim is to evaluate the potential anti-inflammatory effect of EPO observed in animal models of disease. Following PRISMA statements, electronic database Medline via PubMed platform was used to search articles with the research expression ((erythropoietin [MeSH Terms]) AND (inflammation [MeSH Terms]) AND (disease models, animal [MeSH Terms])). The inclusion criteria were original articles, studies where EPO was administered, studies where inflammation was studied and/or evaluated, non-clinical studies in vivo with rodents, and articles published in English. Thirty-six articles met the criteria for qualitative analysis. Exogenous EPO was used in models of sepsis, traumatic brain injury, and autoimmune neuritis, with an average of 3000 IU/Kg for single and multiple doses, using mice and rats. Biomarkers such as immune-related effectors, cytokines, reactive oxygen species, prostaglandins, and other biomarkers were assessed. EPO has been recognized as a multifunctional cytokine with anti-inflammatory properties, showing its significant effect both in acute and chronic models of inflammation. Further non-clinical studies are suggested for the enlightenment of anti-inflammatory mechanisms of EPO in lower doses, allowing us to understand the translational data for humans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva I, Alípio C, Pinto R, Mateus V. Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic review. Biomed Pharmacother. 2021;139:111558.pt_PT
dc.identifier.doi10.1016/j.biopha.2021.111558pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13309
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIPL/2020/cEPO_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332221003437?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectErythropoietinpt_PT
dc.subjectInflammationpt_PT
dc.subjectNon-clinical studies in vivopt_PT
dc.subjectAnimal modelpt_PT
dc.subjectRodentspt_PT
dc.subjectIPL/2020/cEPO_ESTeSLpt_PT
dc.titlePotential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage111558pt_PT
oaire.citation.titleBiomedicine & Pharmacotherapypt_PT
oaire.citation.volume139pt_PT
person.familyNameda Silva
person.familyNamePinho Mateus
person.givenNameInês Filipa Janeiro da Silva
person.givenNameVanessa Alexandra
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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