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Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice

2022-06Journal article Open access
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dc.contributor.authorMateus, Vanessa
dc.contributor.authorEstarreja, João
dc.contributor.authorSilva, Inês
dc.contributor.authorGonçalves, Fernando
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorPinto, Rui
dc.date.accessioned2022-06-20T14:10:17Z
dc.date.available2022-06-20T14:10:17Z
dc.date.issued2022-06
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractBackground: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder represented by Crohn’s disease and ulcerative colitis. Currently, there is no cure and pharmacological treatment aims to induce and maintain remission in patients. Because the therapy reveals relatively high toxicity, during a long-term utilization, it is essential to investigate new pharmacological approaches. Polyphenols, commonly present in red wine, have shown health-beneficial effects related to their antioxidant and anti-inflammatory effects through the inhibition of NF-kB activation, COX-2, and iNOS induction. In this sense, it would be interesting to study their effects in an IBD context. Therefore, this study aims to evaluate the effects of an aqueous extract of phenolic compounds in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced model of colitis. Method: Experimental colitis was induced in mice through an intrarectal administration of TNBS and then the mice were treated with an aqueous extract of phenolic compounds intraperitoneally for four days. Results and Discussion: The extract demonstrated an anti-inflammatory effect, reduced TNF-α levels in the colon, and had a beneficial effect on the extraintestinal manifestations related to IBD, without any significant side effects. The extract of phenolic compounds demonstrated to be a valuable object of study for the management of IBD in the future.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMateus V, Estarreja J, Silva I, Gonçalves F, Teixeira-Lemos E, Pinto R. Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice. Curr Issues Mol Biol. 2022;44(6):2745-58.pt_PT
dc.identifier.doi10.3390/cimb44060188pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14714
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1467-3045/44/6/188pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectPolyphenolspt_PT
dc.subjectRed winept_PT
dc.subjectColitispt_PT
dc.subjectInflammationpt_PT
dc.subjectTNBS-induced colitispt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2758pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage2745pt_PT
oaire.citation.titleCurrent Issues in Molecular Biologypt_PT
oaire.citation.volume44pt_PT
person.familyNamePinho Mateus
person.familyNameEstarreja
person.familyNameda Silva
person.givenNameVanessa Alexandra
person.givenNameJoão
person.givenNameInês Filipa Janeiro da Silva
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.ciencia-idEB19-EDA2-704B
person.identifier.ciencia-idC010-323F-3266
person.identifier.orcid0000-0002-3204-3772
person.identifier.orcid0000-0002-8283-3174
person.identifier.orcid0000-0001-7049-2512
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublicationd16a20d0-ac73-4989-b83d-abeab53139f7
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication.latestForDiscovery995e1831-ff5b-49e7-a6e3-8bc692212204

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