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Automatic versus semi-automatic method for the striatum specific uptake ratio quantification based on [123I]FP-CIT SPECT images

2019-04Journal article Restricted access
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dc.contributor.authorElias, Maria
dc.contributor.authorJorge, Pedro M.
dc.contributor.authorFigueiredo, Sérgio
dc.contributor.authorOliveira, Luis
dc.contributor.authorPereira, Edgar L.
dc.date.accessioned2019-05-27T15:27:40Z
dc.date.available2019-05-27T15:27:40Z
dc.date.issued2019-04
dc.description.abstractThe aim of this work was to implement an automatic application (AA) for the quantification of the striatum transaxial slices based on [123 I]FP-CIT SPECT (Single Photon Emission Tomography) images. A sample of 68 subjects with and without pathology was collected from the nuclear medicine department of the Hospital Particular de Almada. In order to compare the striatum specific uptake ratios (SUR), a semi-automatic application (SAA) was also developed allowing manual adjustments by a specialist operator. The obtained results were compared with the DaTSCAN ® V4 application, from General Electric Healthcare. The experimental results based on SUR demonstrate that the AA can successfully discriminate healthy patients from the pathological subjects. Additionally, a strong correlation was verified between the AA and the semi-automatic methods (DaTSCAN ® V4 and the SAA). These methods also evidence intra and inter-operator variability, suppressed by the AA. The proposed methodology for segmentation and quantification of the striatum transaxial images obtained by [123 I]FP-CIT SPECT demonstrated that the developed application can accurately complement the visual analysis, requiring future optimization.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationElias M, Jorge PM, Figueiredo S, Oliveira L, Pereira EL. Automatic versus semi-automatic method for the striatum specific uptake ratio quantification based on [123I]FP-CIT SPECT images. In: ENBENG 2019 – Proceedings of the 6th IEEE Portuguese Meeting on Bioengineering, Instituto Superior de Engenharia de Lisboa (ISEL), Portugal, February 22-23, 2019. Article no. 8692477.pt_PT
dc.identifier.doi10.1109/ENBENG.2019.8692477pt_PT
dc.identifier.isbn9781538685068
dc.identifier.urihttp://hdl.handle.net/10400.21/10072
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIEEEpt_PT
dc.relation.publisherversionhttps://ieeexplore.ieee.org/document/8692477pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNuclear medicinept_PT
dc.subjectSingle photon emission computed tomographypt_PT
dc.subjectAutomatic applicationpt_PT
dc.subjectSpecific uptake ratiopt_PT
dc.subjectStriatum transaxial imagespt_PT
dc.subjectDaTSCAN V4 applicationpt_PT
dc.titleAutomatic versus semi-automatic method for the striatum specific uptake ratio quantification based on [123I]FP-CIT SPECT imagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4pt_PT
oaire.citation.startPage1pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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