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Comparison of the serum whole molecular composition with the serum metabolome to acquire the pathophysiological state

2024-12Conference paper Open access
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authorProfile.emailbiblioteca@isel.pt
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorCorreia, Inês
dc.contributor.authorHenrique Fonseca, Tiago Alexandre
dc.contributor.authorPataco, Jéssica
dc.contributor.authorOliveira, Mafalda
dc.contributor.authorCaldeira, Viviana
dc.contributor.authorDomingues, N.
dc.contributor.authorVon Rekowski, Cristiana
dc.contributor.authorAraújo, Rúben Alexandre Dinis
dc.contributor.authorBento, Luís
dc.contributor.authorCalado, Cecília
dc.contributor.editorDomingues, Nuno
dc.contributor.editorTomar, Rajesh Singh
dc.contributor.editorMahamud, Tosaporn
dc.date.accessioned2025-04-07T07:18:32Z
dc.date.available2025-04-07T07:18:32Z
dc.date.issued2024-12
dc.description.abstractOmics Sciences serve as an essential tool to advance precision medicine. Since conventional omics sciences rely on laborious, complex and time-consuming analytical processes, this study evaluated whether the serum molecular fingerprint, captured by FTIR spectroscopy, could predict mortality risk in critically ill patients. Both the whole serum and the serum metabolome (i.e., serum after removal of macromolecules) were analyzed. PCA-LDA models demonstrated strong performance in predicting patients’ pathophysiological state. A significantly more accurate model for predicting the patients’ pathophysiological state was achieved using the serum metabolome (94%) compared to the whole serum (81%). This is consistent with metabolomics, which provides a more direct view of the systems’ functionality. These promising results highlight the importance of FTIR spectroscopy analysis of the serum metabolome, offering a rapid, cost-effective, and high-throughput method for assessing patients' pathophysiological state.eng
dc.identifier.citationCorreia, I. et al. Comparison of the serum whole molecular composition with the serum metabolome to acquire the pathophysiological state. In 4th ROME International Conference on Challenges in Engineering, Medical, Economics and Education: Research & Solutions, Rome, Italy, 2024, pp. 43-49, doi: https://doi.org/10.17758/EARES19
dc.identifier.doi10.17758/EARES19
dc.identifier.isbn978-989-9121-43-0
dc.identifier.urihttp://hdl.handle.net/10400.21/21760
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEARET
dc.relation.hasversionhttps://earet.org/proceedingspdf.php?id=415
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomarkers
dc.subjectFTIR spectroscopy
dc.subjectMetabolome
dc.subjectIntensive care unit
dc.titleComparison of the serum whole molecular composition with the serum metabolome to acquire the pathophysiological stateeng
dc.typeconference paper
dspace.entity.typePublication
oaire.citation.conferenceDate2024-12-04
oaire.citation.conferencePlaceRome, Italy
oaire.citation.endPage49
oaire.citation.startPage43
oaire.citation.title4th ROME International Conference on Challenges in Engineering, Medical, Economics and Education: Research & Solutions [CEMEERS-24b)
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameHenrique Fonseca
person.familyNameVon Rekowski
person.familyNameAraújo
person.familyNameCalado
person.givenNameTiago Alexandre
person.givenNameCristiana
person.givenNameRúben Alexandre Dinis
person.givenNameCecília
person.identifier1960990
person.identifier130332
person.identifier.ciencia-id8F1D-1D48-8551
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.ciencia-id9418-E320-3177
person.identifier.orcid0000-0003-0741-2211
person.identifier.orcid0009-0009-6843-1935
person.identifier.orcid0000-0002-9369-6486
person.identifier.orcid0000-0002-5264-9755
person.identifier.ridE-2102-2014
person.identifier.scopus-author-id6603163260
relation.isAuthorOfPublicationd4a391dd-4551-44df-a326-c17e796b0945
relation.isAuthorOfPublicationaa62d0cd-948b-45a0-9717-459b247dae86
relation.isAuthorOfPublication9998e940-5e65-4661-8308-afcb56d5df01
relation.isAuthorOfPublicatione8577257-c64c-4481-9b2b-940fedb360cc
relation.isAuthorOfPublication.latestForDiscoveryd4a391dd-4551-44df-a326-c17e796b0945

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