Selenium role in an human biomonitoring study applied to occupational health

Ladeira, Carina; Viegas, Susana; Carolino, Elisabete; Gomes, Manuel C.; Brito, Miguel

http://hdl.handle.net/10400.21/4874

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Abstract(s)

Selenium functions as a co-factor for the reduction of antioxidant enzymes and is an important component of antioxidant enzymes. Dietary selenium significantly inhibits the induction of skin, liver, colon, and mammary tumours in experimental animals by a number of different carcinogens, as well as the induction of mammary tumours by viruses. Selenium shows a “U” shaped curve for functionality, whereby too little is as damaging as too much. At optimal levels, selenium may protect against the formation of DNA adducts, DNA or chromosome breakage, chromosome gain or loss, mitochondrial DNA, and telomere length and function. Aim of study: Investigate the relation between selenium and genotoxic effects in a human biomonitoring study applied to occupational health.

Keywords

Occupational health Occupational exposure Genotoxic effect Selenium

URI

http://hdl.handle.net/10400.21/4874

Citation

Ladeira C, Viegas S, Carolino E, Gomes MC, Brito M. Selenium role in an human biomonitoring study applied to occupational health. In Selenium and Selenoproteins in Health and Disease Conference, FFULisboa Auditorium, 9th April 2015.