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Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

2014-08Journal article Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorPádua, Mário
dc.contributor.authorVeiga, Ana Costa
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Mário
dc.date.accessioned2014-08-06T11:00:57Z
dc.date.issued2014-08
dc.description.abstractDespite the classification as known or suspected human carcinogens, by the International Agency for Research on Cancer, the antineoplastic drugs are extensively used in cancer treatment due to their specificity and efficacy. As human carcinogens, these drugs represent a serious threat to the healthcare workers involved in their preparation and administration. This work aims to contribute to better characterize the occupational exposure of healthcare professionals to antineoplastic drugs, by assessing workplace surfaces contamination of pharmacy and administration units of two Portuguese hospitals. Surface contamination was assessed by the determination of cyclophosphamide, 5-fluorouracil, and paclitaxel. These three drugs were used as surrogate markers for surfaces contamination by cytotoxic drugs. Wipe samples were taken and analyzed by HPLCDAD. From the total of 327 analyzed samples, in 121 (37%) was possible to detect and quantify at least one drug. Additionally, 28 samples (8.6 %) indicate contamination by more than one antineoplastic drug, mainly in the administration unit, in both hospitals. Considering the findings in both hospitals, specific measures should be taken, particularly those related with the promotion of good practices and safety procedures and also routine monitoring of surfaces contamination in order to guarantee the appliance of safety measures.por
dc.identifier.citationViegas S, Pádua M, Veiga AC, Carolino E, Gomes M. Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals. Environ Monit Assess. 2014;186(11):7807-18.por
dc.identifier.doi10.1007/s10661-014-3969-1en
dc.identifier.urihttp://hdl.handle.net/10400.21/3731
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relation.publisherversionhttp://link.springer.com/article/10.1007/s10661-014-3969-1por
dc.subjectCytotoxic drugspor
dc.subjectSurfaces contaminationpor
dc.subjectWipe samplingpor
dc.subjectOccupational exposure assessmentpor
dc.titleAntineoplastic drugs contamination of workplace surfaces in two Portuguese hospitalspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7818
oaire.citation.startPage7807
oaire.citation.titleEnvironmental Monitoring and Assessmentpor
oaire.citation.volume186
person.familyNameViegas
person.familyNameCarolino
person.givenNameSusana
person.givenNameElisabete
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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