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Advisor(s)
Abstract(s)
Herein we disclose a new pathway for the design of dapsone co-crystals exploring the formation of N-H center dot center dot center dot O/N interactions using amide and pyridinic derivatives as potential co-formers. Two new co-crystals of dapsone, a sulfonamide antibiotic, with epsilon-caprolactam and 4,4'-bipyridine have been synthesized preferentially by traditional solution techniques, but mechanochemistry has also been addressed. The full structural characterization of these forms is discussed and shows that: (a) in the co-crystal with epsilon-caprolactam the typical N-NH2 center dot center dot center dot O-SO2 interactions of dapsone molecules and the cages formed between them are disrupted by a new N-NH2 center dot center dot center dot O-CONH interaction, in which epsilon-caprolactam molecules further form amide center dot center dot center dot amide R-2(2)(8) synthons and (b) in the co-crystal with 4,4'-bipyridine, the N-NH2 center dot center dot center dot O-SO2 interactions between dapsone molecules are maintained and additional N-NH2 center dot center dot center dot N-pyridine interactions are responsible for the formation of 4,4'-bipyridine channels between dapsone cages. Moreover, the thermal stability of these co-crystals is also discussed, showing that the co-formers leave the structure and hence the reported melting corresponds to the melting of pure dapsone.
Description
Agência Financiadora: Fundação para a Ciência e a Tecnologia - Pest-OE/QUI/UI0100/2013;
PTDC/CTM-BPC/122447/2010;
RECI/QEQ-QIN/0189/2012;
SFRH/BPD/78854/2011
Keywords
Enantioselective Inclusion Phamaceutical Phases Sulfoxides Refinement Cocrystals Acid
Citation
MARTINS, Inês; [et al] - An insight into dapsone co-crystals: sulfones as participants in supramolecular interactions. CrystEngComm. Vol. 15, nr. 40 (2013), p. 8173-8179.
Publisher
Royal Soc Chemistry