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HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects

2025-02Journal article Restricted access
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dc.contributor.authorViegas, Susana
dc.contributor.authorMartins, Carla
dc.contributor.authorRibeiro, Edna
dc.contributor.authorLadeira, Carina
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorNogueira, Ana
dc.contributor.authorSantos, Sílvia
dc.contributor.authorTavares, Ana
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorAfonso, Catarina Maia
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2024-12-27T14:32:45Z
dc.date.available2024-12-27T14:32:45Z
dc.date.issued2025-02
dc.descriptionThis project received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 (Human Biomonitoring for European Union, HBM4EU) and received co-funding from the authors’ organizations and/or ministries.pt_PT
dc.description.abstractIn the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy actions at the national and European levels. This work describes the Portuguese contribution to the study, which aimed to assess workers' exposure to Cr, by using exposure biomarkers (urinary chromium [U-Cr]), and industrial hygiene samples (air and hand wipes) and to link exposure to potential long-term health effects by using effect biomarkers. Exposure determinants influencing exposure were explored from the contextual information and human biomonitoring data. The ultimate goal of the study was to appraise the risk management measures contributing to minimizing exposure and protecting workers' health. Several occupational settings and activities were considered, including plating, welding, and painting. A control group from the Portuguese general population was also included. Data on age, sex, and smoking habits from both groups were considered in the statistical analysis. Information on the risk management measures available for workers was collected and used to identify the ones that mainly contributed to reducing exposure. Environmental monitoring and human biomonitoring revealed that painters were the highest exposed group. The use of respiratory protection equipment showed an influence on total U-Cr levels for workers involved in painting activities. Concerning early health effects, the painters presented also a significantly higher level of DNA and chromosomal damage in peripheral blood cells, as compared to the control group, suggesting a plausible association between exposure to Cr(VI) and early genotoxic effects. The results showed that workers are exposed to Cr(VI) in those occupational settings. These findings point to the need to improve the prevention and risk management measures and the implementation and enforcement of new regulatory actions at the national level.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas S, Martins C, Ribeiro E, Ladeira C, Pinhal H, Nogueira A, et al. HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects. Ann Work Expo Health. 2025;69(2):147-59.pt_PT
dc.identifier.doi10.1093/annweh/wxae091pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/18086
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationHuman Biomonitoring for European Union, HBM4EU (grant agreement no. 733032)pt_PT
dc.relation.publisherversionhttps://academic.oup.com/annweh/advance-article-abstract/doi/10.1093/annweh/wxae091/7917522?redirectedFrom=fulltext&login=truept_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectEffect biomarkerspt_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectHBM4EU chromates studypt_PT
dc.titleHBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effectspt_PT
dc.typejournal article
degois.publication.firstPage147
degois.publication.issue2
degois.publication.lastPage159
degois.publication.volume69
dspace.entity.typePublication
oaire.citation.titleAnnals of Work Exposures and Healthpt_PT
person.familyNameViegas
person.familyNameRibeiro
person.familyNameLadeira
person.givenNameSusana
person.givenNameEdna
person.givenNameCarina
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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