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EDCs mixtures: a stealthy hazard for human health?

2017-02Artigo científico Acesso aberto
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dc.contributor.authorRibeiro, Edna
dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.date.accessioned2017-05-17T09:34:17Z
dc.date.available2017-05-17T09:34:17Z
dc.date.issued2017-02
dc.description.abstractEndocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally (e.g., phytoestrogens), while others are industrial substances and plasticizers commonly utilized worldwide to which human exposure, particularly at low-doses, is omnipresent, persistent and occurs in complex mixtures. EDCs can interfere with/or mimic estrogenic hormones and, consequently, can simultaneously trigger diverse signaling pathways which result in diverse and divergent biological responses. Additionally, EDCs can also bioaccumulate in lipid compartments of the organism forming a mixed “body burden” of contaminants. Although the independent action of chemicals has been considered the main principle in EDCs mixture toxicity, recent studies have demonstrated that numerous effects cannot be predicted when analyzing single compounds independently. Co-exposure to these agents, particularly in critical windows of exposure, may induce hazardous health effects potentially associated with a complex “body burden” of different origins. Here, we performed an exhaustive review of the available literature regarding EDCs mixtures exposure, toxicity mechanisms and effects, particularly at the most vulnerable human life stages. Although the assessment of potential risks to human health due to exposure to EDCs mixtures is a major topic for consumer safety, information regarding effective mixtures effects is still scarce.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro E, Ladeira C, Viegas S. EDCs mixtures: a stealthy hazard for human health? Toxics. 2017;5(1):5.pt_PT
dc.identifier.doi10.3390/toxics5010005pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.21/7016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2305-6304/5/1/5pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectEndocrine disrupting chemicalspt_PT
dc.subjectMixturespt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectWindows of exposurept_PT
dc.subjectRisk assessmentpt_PT
dc.titleEDCs mixtures: a stealthy hazard for human health?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage5pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume5pt_PT
person.familyNameRibeiro
person.familyNameLadeira
person.familyNameViegas
person.givenNameEdna
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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