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Advisor(s)
Abstract(s)
A transfusão de componentes sanguíneos é uma terapêutica por norma segura, muito usada na prática clínica hospitalar, mas não totalmente isenta à ocorrência de Reações Adversas à Transfusão. Com o objetivo de identificar e caracterizar as reações adversas à transfusão mais frequentes em Portugal, entre os anos 2017 e 2021, foi realizado um estudo observacional descritivo das reações adversas à transfusão ocorridas em Portugal nesse período, através da análise dos Relatórios Anuais de Atividade Transfusional do Sistema Português de Hemovigilância. A população deste estudo correspondeu ao universo dos Serviços de Sangue e Serviço de Medicina Transfusional, Serviços de Sangue, Serviços de Medicina Transfusional e Pontos Transfusionais registados na base de dados do Sistema Português de Hemovigilância, que notificaram Reações Adversas à Transfusão. No período em estudo foram notificadas 1695 Reações Adversas à Transfusão, sendo que a maioria das notificações ocorreram na Região de Lisboa e Vale do Tejo. Dos resultados obtidos verificou-se que a reação febril não hemolítica foi a reação mais notificada, sendo os concentrados eritrocitários o componente sanguíneo responsável pelo maior número de reações. Relativamente à gravidade constatou-se que 1490 das reações notificadas foram consideradas não graves e que a faixa etária em que ocorreram maior número de reações é nos doentes com idades superiores a 50 anos. Os resultados obtidos permitiram concluir que a consciencialização dos profissionais envolvidos na cadeia transfusional, para a importância do correto cumprimento das normas e procedimentos para a melhoria continua é fundamental para diminuir a ocorrência de reações adversas à transfusão.
ABSTRACT - The transfusion of blood components is generally a safe therapy, widely used in clinical hospital practice, but not entirely exempt from the occurrence of Adverse Reactions to Transfusion. To identify and characterize the most frequent adverse transfusion reactions in Portugal, between the years 2017 and 2021, a descriptive observational study of the adverse transfusion reactions that occurred in Portugal during this period was carried out, through the analysis of the Annual Transfusion Activity Reports of the Portuguese Hemovigilance System. The population of this study corresponded to the universe of Blood Services and Transfusion Medicine Services, Blood Services, Transfusion Medicine Services, and Transfusion Points registered in the database of the Portuguese Hemovigilance System, which notified Adverse Reactions to Transfusion. During the study period, 1695 Adverse Reactions to Transfusion were reported, with most notifications occurring in the Lisbon and Vale do Tejo Region. From the results obtained, it was verified that the non-hemolytic febrile reaction was the most reported reaction, with erythrocyte concentrates being the blood component responsible for the highest number of reactions. Concerning severity, it was found that 1490 of the reported reactions were considered non-serious and that the age group in which the highest number of reactions occurred is in patients aged over 50 years. The results obtained allowed us to conclude that the awareness of professionals involved in the transfusion chain to the importance of correct compliance with norms and procedures for continuous improvement is essential to reduce the occurrence of adverse transfusion reactions.
ABSTRACT - The transfusion of blood components is generally a safe therapy, widely used in clinical hospital practice, but not entirely exempt from the occurrence of Adverse Reactions to Transfusion. To identify and characterize the most frequent adverse transfusion reactions in Portugal, between the years 2017 and 2021, a descriptive observational study of the adverse transfusion reactions that occurred in Portugal during this period was carried out, through the analysis of the Annual Transfusion Activity Reports of the Portuguese Hemovigilance System. The population of this study corresponded to the universe of Blood Services and Transfusion Medicine Services, Blood Services, Transfusion Medicine Services, and Transfusion Points registered in the database of the Portuguese Hemovigilance System, which notified Adverse Reactions to Transfusion. During the study period, 1695 Adverse Reactions to Transfusion were reported, with most notifications occurring in the Lisbon and Vale do Tejo Region. From the results obtained, it was verified that the non-hemolytic febrile reaction was the most reported reaction, with erythrocyte concentrates being the blood component responsible for the highest number of reactions. Concerning severity, it was found that 1490 of the reported reactions were considered non-serious and that the age group in which the highest number of reactions occurred is in patients aged over 50 years. The results obtained allowed us to conclude that the awareness of professionals involved in the transfusion chain to the importance of correct compliance with norms and procedures for continuous improvement is essential to reduce the occurrence of adverse transfusion reactions.
Description
Mestrado em Tecnologias Clínico-Laboratoriais
Keywords
Transfusão Reação adversa Componentes sanguíneos Notificação Transfusion Adverse reaction Blood components Notification Portugal
Citation
Gonçalves CC. Caracterização das reações adversas à transfusão em Portugal [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2023.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa