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Occupational exposure to Aspergillus section Fumigati: tackling the knowledge gap in Portugal

2021-03Artigo científico Acesso restrito
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dc.contributor.authorViegas, Carla
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorViegas, Susana
dc.date.accessioned2021-02-13T17:11:57Z
dc.date.available2021-02-13T17:11:57Z
dc.date.issued2021-03
dc.descriptionProject “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).pt_PT
dc.descriptionUIDB/05608/2020 and UIDP/05608/2020.pt_PT
dc.description.abstractAspergillus section Fumigati is one of the sections of the Aspergillus genus most often associated with respiratory symptoms. The azole-resistant clinical isolates in this section have been widely described worldwide. More recently, the environmental origin of azole resistance has been correlated with the development of fungal diseases and therapeutic failure. This paper presents a review of several studies performed in Portuguese occupational environments focusing on occupational exposure to this section and give guidance to exposure assessors and industrial hygienists to ensure an accurate exposure assessment. Future studies should tackle the limitations concerning the assessment of occupational exposure to the Fumigati section, in order to allow the implementation of adequate risk management measures. In the light of the results of previous studies, the following approach is proposed to ensure an accurate exposure assessment: a) a combination of active and passive sampling methods appropriate to each occupational environment; b) the use, in parallel, of culture-based methods and molecular tools to overcome the limitations of each method; c) evaluation of the mycobiota azole resistance profile; and d) consider the possible simultaneous presence of mycotoxins produced by this section when assessing workers occupational exposure. In sum, preventing the development of fungal strains resistant to azoles will only be achieved with a holistic approach. An adequate "One Health approach" can contribute positively to concerted actions in different sectors, by reducing the use of fungicides through the introduction of crops and agricultural practices that prevent fungal colonization, and by promoting the rational use of antifungal drugs in human and animal health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas C, Caetano LA, Viegas S. Occupational exposure to Aspergillus section Fumigati: tackling the knowledge gap in Portugal. Environ Res. 2021;194:110674. [Online ahead of print].pt_PT
dc.identifier.doi10.1016/j.envres.2020.110674pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12844
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationProject “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL)pt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935120315711?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAspergillus section Fumigatipt_PT
dc.subjectAzole resistance profilept_PT
dc.subjectCulture-based methodspt_PT
dc.subjectMolecular toolspt_PT
dc.subjectOccupational exposurept_PT
dc.subjectSampling methodspt_PT
dc.subjectIPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleOccupational exposure to Aspergillus section Fumigati: tackling the knowledge gap in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage110674pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume194pt_PT
person.familyNameViegas
person.familyNameAranha Caetano
person.familyNameViegas
person.givenNameCarla
person.givenNameLiliana
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0003-1496-2609
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridB-7217-2013
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id55443609700
person.identifier.scopus-author-id35270591500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery6517c656-f913-4f54-8682-77c2856c9e4c

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