Publication
The importance of Helicobacter pylori's genetic variability for the construction of an efficient vaccine
| dc.contributor.author | Vaz, Filipa | |
| dc.contributor.author | Couto, Andreia | |
| dc.contributor.author | Calado, Cecília | |
| dc.date.accessioned | 2020-07-30T14:55:49Z | |
| dc.date.available | 2020-07-30T14:55:49Z | |
| dc.date.issued | 2012-10-18 | |
| dc.description.abstract | Helicobacter pylori is responsible for several gastric diseases. The main constraints of vaccine trials against this pathogen are mainly due to the bacterium high antigenic variability and to down-regulation of the host immune responses. To counteract these factors we propose a DNA vaccine able to induce a balanced humoural and citotoxic specific immune responses, based on multi-antigens. The selection of the antigens NapA, HpaA, VacA and HomB were conducted based on immunoproteomic data and the protein role on infection and pathogenesis. A fragment of each target-antigen was selected by in silico methods based on the maximization of the gene conservation and antigenicity. The set of these small fragments will be presented as a vaccine based on several conserved epitopes of multi-antigenic targets, and consequently representative of the bacterium antigenic variability. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | VAZ, Filipa; COUTO, Andreia; CALADO, Cecília R. C. – The importance of Helicobacter pylori's genetic variability for the construction of an efficient vaccine. In 2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG). Coimbra, Portugal: IEEE, 2012. ISBN 978-1-4673-4524-8. Pp. 1-5 | pt_PT |
| dc.identifier.doi | 10.1109/ENBENG.2012.6331369 | pt_PT |
| dc.identifier.isbn | 978-1-4673-4524-8 | |
| dc.identifier.isbn | 978-1-4673-4526-2 | |
| dc.identifier.uri | http://hdl.handle.net/10400.21/12120 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Institute of Electrical and Electronics Engineers | pt_PT |
| dc.relation.publisherversion | https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6331369 | pt_PT |
| dc.subject | Helicobacter pylori | pt_PT |
| dc.subject | DNA vaccine | pt_PT |
| dc.subject | Multiantigeni | pt_PT |
| dc.subject | Genetic variability | pt_PT |
| dc.subject | Conserved epitopes | pt_PT |
| dc.title | The importance of Helicobacter pylori's genetic variability for the construction of an efficient vaccine | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIO%2F69242%2F2006/PT | |
| oaire.citation.conferencePlace | 23-25 Feb. 2012 - Coimbra, Portugal | pt_PT |
| oaire.citation.endPage | 5 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | 2012 IEEE 2nd Portuguese Meeting in Bioengineering (ENBENG) | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Calado | |
| person.givenName | Cecília | |
| person.identifier | 130332 | |
| person.identifier.ciencia-id | 9418-E320-3177 | |
| person.identifier.orcid | 0000-0002-5264-9755 | |
| person.identifier.rid | E-2102-2014 | |
| person.identifier.scopus-author-id | 6603163260 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | e8577257-c64c-4481-9b2b-940fedb360cc | |
| relation.isAuthorOfPublication.latestForDiscovery | e8577257-c64c-4481-9b2b-940fedb360cc | |
| relation.isProjectOfPublication | e934d4a3-07d0-4c5d-8183-e76b3b0bf237 | |
| relation.isProjectOfPublication.latestForDiscovery | e934d4a3-07d0-4c5d-8183-e76b3b0bf237 |
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