Publication
Numerical simulation of excitation-contraction in isolated cardiomyocytes
| dc.contributor.author | Rodrigues, José Alberto | |
| dc.contributor.author | Oliveira, Joana | |
| dc.date.accessioned | 2019-09-04T08:18:49Z | |
| dc.date.available | 2019-09-04T08:18:49Z | |
| dc.date.issued | 2019-09 | |
| dc.description | Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2018 do Instituto Politécnico de Lisboa. Código de referência IPL/2018/IGACFC_ISEL | |
| dc.description.abstract | We present and study a mathematical model to simulate the calcium flux and contractile activity of the cardiomyocyte, resorting on the Finite Element Method. This Model of cardiac cells provide the possibility to understand the biochemistry and biomechanics of cardiac cells and cardiovascular diseases. Heart Failure is considered the ultimate cardiac disease, a condition with no effective cure which is highly related with the function of cardiomyocytes and consequently with the concentration of calcium, affecting the contractile activity of the cardiomyocyte. In order to test our model’s performance, several tests were applied varying the local active cellular tension driven by the intracellular calcium concentration and the localization of the main calcium influx. The results are expressed in the graphics of calcium concentration over time, maximum cardiomyocyte contraction and the gradient of calcium diffusion. Our results show that the behaviour of our models is faithful to what is known to be true with cell’s physiology and pathological conditions. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | RODRIGUES, José Alberto; OLIVEIRA, Joana – Numerical simulation of excitation-contraction in isolated cardiomyocytes. Statistics, Optimization and Information Computing. ISSN 2310-5070. Vol. 7 (2019), pp. 604-616 | pt_PT |
| dc.identifier.doi | 10.19139/soic-2310-5070-835 | pt_PT |
| dc.identifier.issn | 2310-5070 | |
| dc.identifier.issn | 2311-004X | |
| dc.identifier.uri | http://hdl.handle.net/10400.21/10463 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | International Academic Press | pt_PT |
| dc.relation | Projeto financiado no âmbito do Concurso de Projetos de Investigação, Desenvolvimento, Inovação & Criação Artística (IDI&CA) financiados pelo Instituto Politécnico de Lisboa. IPL/2018/IGACFC_ISEL | pt_PT |
| dc.relation.publisherversion | http://iapress.org/index.php/soic/article/viewFile/soic.20190907/550 | pt_PT |
| dc.subject | Biomedical engineering | pt_PT |
| dc.subject | Ca2+ | pt_PT |
| dc.subject | Oscillations | pt_PT |
| dc.subject | Mechano-chemical mathematical model | pt_PT |
| dc.subject | Finite element methods. | pt_PT |
| dc.title | Numerical simulation of excitation-contraction in isolated cardiomyocytes | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 616 | pt_PT |
| oaire.citation.startPage | 604 | pt_PT |
| oaire.citation.title | Statistics, Optimization and Information Computing | pt_PT |
| oaire.citation.volume | 7 | pt_PT |
| person.familyName | Rodrigues | |
| person.givenName | José Alberto | |
| person.identifier.ciencia-id | 241B-90A4-D998 | |
| person.identifier.orcid | 0000-0001-5630-7149 | |
| person.identifier.scopus-author-id | 7202707426 | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 6743a818-d8d5-489f-829e-43391b3257cc | |
| relation.isAuthorOfPublication.latestForDiscovery | 6743a818-d8d5-489f-829e-43391b3257cc |