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Association between high myopia and non-alcoholic fatty liver disease in adolescents

2026-09Artigo científico Acesso embargado
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGuo, Ting-Han
dc.contributor.authorDong, Xing-Xuan
dc.contributor.authorLi, Dan-Lin
dc.contributor.authorGrzybowski, Andrzej
dc.contributor.authorLança, Carla
dc.contributor.authorQin, Yu
dc.contributor.authorZheng, Ya-Jie
dc.contributor.authorLiang, Gang
dc.contributor.authorPan, Chen-Wei
dc.date.accessioned2026-10-09T11:45:15Z
dc.date.available2026-10-09T11:45:15Z
dc.date.issued2026-09
dc.descriptionThis research was supported by the China Postdoctoral Science Foundation, No. 77 General Fund (Grant No. 2025M770738), the Natural Science Research Project of Higher Education Institutions of Jiangsu Province (General Program) [Grant No. 25KJB330007], and the Joint Key Project of Yunnan Provincial Department of Science and Technology and Kunming Medical University on Applied Basic Research [Grant No. 202301AY070001-017]. The sponsor or funding organization had no role in the design or conduct of this research.
dc.description.abstractPurpose: To investigate the association between high myopia and non-alcoholic fatty liver disease (NAFLD) in adolescents and to explore potential metabolic mechanisms. Methods: A total of 550 freshmen from Dali University were included. Data on refractive status, questionnaires, and serum metabolomics were collected. Multivariable logistic regression was used to assess the independent association between high myopia and NAFLD. Mediation analysis was performed to explore potential mediating metabolites, and enrichment analysis was utilized to explore key metabolic pathways. Results: The prevalence of NAFLD in the study population was 11.3%. High myopia was associated with higher odds of NAFLD (OR = 2.81, 95% CI: 1.34-5.86). Mediation analysis suggested 15 metabolites as potential mediators, with L-phenylalanine (mediating effect: 23.0%) and L-leucine (mediating effect: 16.7%) showing the largest effects. Enrichment analysis revealed that these key metabolites were primarily enriched in pathways such as aromatic and branched-chain amino acid metabolism, lysine degradation, and pantothenate and CoA biosynthesis. Conclusion: High myopia was associated with increased odds of NAFLD in adolescents, and this relationship may be partially mediated by abnormalities in amino acid and energy metabolism, suggesting potential metabolic links between ocular and hepatic conditions.eng
dc.description.sponsorshipThis research was supported by the China Postdoctoral Science Foundation, No. 77 General Fund (Grant No. 2025M770738), the Natural Science Research Project of Higher Education Institutions of Jiangsu Province (General Program) [Grant No. 25KJB330007], and the Joint Key Project of Yunnan Provincial Department of Science and Technology and Kunming Medical University on Applied Basic Research [Grant No. 202301AY070001-017]. The sponsor or funding organization had no role in the design or conduct of this research.
dc.identifier.citationGuo TH, Dong XX, Li DL, Grzybowski A, Lanca C, Qin Y, et al. Association between high myopia and non-alcoholic fatty liver disease in adolescents. Ophthalmic Epidemiol. 2026 Sep 23:1-9. Epub ahead of print.
dc.identifier.doi10.1080/09286586.2026.2734829
dc.identifier.issn0928-6586
dc.identifier.issn1744-5086
dc.identifier.urihttp://hdl.handle.net/10400.21/23218
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInforma UK Limited
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/09286586.2026.2734829
dc.relation.ispartofOphthalmic Epidemiology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectOphthalmology
dc.subjectMyopia
dc.subjectHigh myopia
dc.subjectAmino acid metabolism
dc.subjectAdolescents
dc.subjectMetabolomics
dc.subjectNon-alcoholic fatty liver disease
dc.subjectNAFLD
dc.subjectDali University
dc.subjectChina
dc.titleAssociation between high myopia and non-alcoholic fatty liver disease in adolescentseng
dc.typejournal article
dcterms.referenceshttps://doi.org/10.1080/09286586.2026.2734829
dspace.entity.typePublication
oaire.citation.titleOphthalmic Epidemiology
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLança
person.givenNameCarla
person.identifier.ciencia-id601A-6412-BF2F
person.identifier.orcid0000-0001-9918-787X
relation.isAuthorOfPublication0320b455-ee19-4670-8bf2-10dce9de1bec
relation.isAuthorOfPublication.latestForDiscovery0320b455-ee19-4670-8bf2-10dce9de1bec

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