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Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women

2011-02Artigo científico Acesso aberto
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dc.contributor.authorVeiga, Luísa
dc.contributor.authorSilva-Nunes, José
dc.contributor.authorMelão, Alice
dc.contributor.authorOliveira, Ana
dc.contributor.authorDuarte, Leone
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-03T21:02:01Z
dc.date.available2014-01-03T21:02:01Z
dc.date.issued2011-02
dc.description.abstractIntroduction - Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have been identified. The aims of this study were i) to assess PON1 L55M and Q192R polymorphisms as a risk factor for obesity in women; ii) to compare PON1 activity according to the expression of each allele in L55M and Q192R polymorphisms; iii) to compare PON1 activity between obese and normal-weight women. Materials and methods - We studied 75 healthy (35.9±8.2 years) and 81 obese women (34.3±8.2 years). Inclusion criteria for obese subjects were body mass index ≥30 kg/m2 and absence of inflammatory/neoplasic conditions or kidney/hepatic dysfunction. The two PON1 polymorphisms were assessed by real-time PCR with TaqMan probes. PON1 enzymatic activity was assessed by spectrophotometric methods, using paraoxon as a substrate. Results - No significant differences were found for PON1 activity between normal and obese women. Nevertheless, PON1 activity was greater (P<0.01) for the RR genotype (in Q192R polymorphism) and for the LL genotype (in L55M polymorphism). The frequency of allele R of Q192R polymorphism was significantly higher in obese women (P<0.05) and was associated with an increased risk of obesity (odds ratio=2.0 – 95% confidence interval (1.04; 3.87)). Conclusion - 55M and Q192R polymorphisms influence PON1 activity. The allele R of the Q192R polymorphism is associated with an increased risk for development of obesity among Portuguese Caucasian premenopausal women.por
dc.identifier.citationVeiga L, Silva-Nunes J, Melão A, Oliveira A, Duarte L, Brito M. Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women. Eur J Endocrinol. 2011;164(2):213-8.por
dc.identifier.issn1479-683X
dc.identifier.urihttp://hdl.handle.net/10400.21/3063
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherEuropean Society of Endocrinologypor
dc.relation.publisherversionhttp://eje-online.org/content/164/2/213.longpor
dc.subjectAllelespor
dc.subjectAnalysis of variancepor
dc.subjectAryldialkylphosphatasepor
dc.subjectEuropean Continental Ancestry Grouppor
dc.subjectGene frequencypor
dc.subjectGenetic association studiespor
dc.subjectGenetic predisposition to diseasepor
dc.subjectObesitypor
dc.subjectOdds ratiopor
dc.subjectPolymorphism, Single nucleotidepor
dc.subjectReverse transcriptase polymerase chain reactionpor
dc.subjectRisk factorpor
dc.subjectPortugalpor
dc.titleQ192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese womenpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage218por
oaire.citation.startPage213por
oaire.citation.titleEuropean Journal of Endocrinologypor
oaire.citation.volume164por
person.familyNameVeiga
person.familyNameBrito
person.givenNameLuisa
person.givenNameMiguel
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-1153-8343
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridL-2730-2013
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id8318978600
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscoveryaac1914a-275f-4be2-819d-ab41d356b45a

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