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Genotoxic effects of exposure to formaldehyde in two different occupational settings

2012-04Book part Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorLadeira, Carina
dc.contributor.authorGomes, Mário
dc.contributor.authorNunes, Carla
dc.contributor.authorBrito, Miguel
dc.contributor.authorPrista, João
dc.date.accessioned2012-06-18T10:15:57Z
dc.date.available2012-06-18T10:15:57Z
dc.date.issued2012-04
dc.description.abstractFormaldehyde (CH2O), the most simple and reactive aldehyde, is a colorless, reactive and readily polymerizing gas at room temperature (National Toxicology Program [NTP]. It has a pungent suffocating odor that is recognized by most human subjects at concentrations below 1 ppm. Aleksandr Butlerov synthesized the chemical in 1859, but it was August Wilhelm von Hofmann who identified it as the product formed from passing methanol and air over a heated platinum spiral in 1867. This method is still the basis for the industrial production of formaldehyde today, in which methanol is oxidized using a metal catalyst. By the early 20th century, with the explosion of knowledge in chemistry and physics, coupled with demands for more innovative synthetic products, the scene was set for the birth of a new material–plastics. According to the Report on Carcinogens, formaldehyde ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Formaldehyde annual production rises up to 21 million tons worldwide and it has increased in China with 7.5 million tons produced in 2007. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Commercially, formaldehyde is manufactured as an aqueous solution called formalin, usually containing 37% by weight of dissolved formaldehyde. This chemical is present in all regions of the atmosphere arising from the oxidation of biogenic and anthropogenic hydrocarbons. Formaldehyde concentration levels range typically from 2 to 45 ppbV (parts per billion in a given volume) in urban settings that are mainly governed by primary emissions and secondary formation.por
dc.identifier.citationViegas S, Ladeira C, Gomes M, Nunes C, Brito M, Prista J. Genotoxic effects of exposure to formaldehyde in two different occupational settings. In Pesheva M, Dimitrov M, Stoycheva TS, editors. Carcinogen. InTech; 2012. p. 35-54.por
dc.identifier.isbn978-953-51-0658-6
dc.identifier.urihttp://hdl.handle.net/10400.21/1584
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInTechpor
dc.relation.publisherversionhttp://www.intechopen.com/books/carcinogen/genotoxic-effects-of-occupational-exposure-to-formaldehydepor
dc.subjectSaúde ambientalpor
dc.subjectSaúde ocupacionalpor
dc.subjectFormaldeídopor
dc.subjectEnvironmental healthpor
dc.subjectOccupational healthpor
dc.subjectFormaldehydepor
dc.titleGenotoxic effects of exposure to formaldehyde in two different occupational settingspor
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage54por
oaire.citation.startPage35por
person.familyNameViegas
person.familyNameLadeira
person.familyNameBrito
person.givenNameSusana
person.givenNameCarina
person.givenNameMiguel
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typebookPartpor
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relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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