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Interictal spike quantification in continuous spike-wave of sleep (CSWS): clinical usefulness of a wearable EEG device

2020-03Journal article Open access
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dc.contributor.authorCarvalho, Daniel
dc.contributor.authorMendes, Timóteo
dc.contributor.authorDias, Ana I.
dc.contributor.authorLeal, Alberto
dc.date.accessioned2021-03-27T18:42:46Z
dc.date.available2024-03-27T01:30:19Z
dc.date.issued2020-03
dc.description.abstractIntroduction: Continuous spike-wave of sleep (CSWS) syndrome is one of the most common epileptic encephalopathies of childhood. Because the associated cognitive/behavioral disturbances relate more to the amount of spike activity than to seizures, methods of spike quantification gained relevance in diagnosis and monitoring treatment. The conventional methodology for quantification of spike index (SI) relies on repeated full 10-20 long-term ambulatory electroencephalography (aEEG), which is both expensive and poorly tolerated. Objective: The objectives of this study were to demonstrate the clinical value of repeated SI assessments in CSWS and to build and validate a wearable device allowing inexpensive and well-tolerated, repeated quantification. Methods: A group of N = 38 patients with CSWS were submitted to repeated SI quantifications based on aEEG, as seen fit by the medical clinical assistant. Responses to therapy with corticosteroids (N = 10), sulthiame (N = 7), and the ketogenic diet (N = 3) were monitored. We used a conventional method based on a semiautomatic template match spike search. The individual variability in time spans of days (N = 4) or months (N = 10) was assessed and used to determine the meaningful neurophysiological responses to the diverse therapies. A wearable device capable of recording 2 bipolar EEG channels for 24 h was used to simplify SI quantification. Results: Corticosteroids produced the most powerful SI reduction, but large individual variability in both amount and time of onset of clinical response with some patients exhibiting recurrence shortly after therapy. More frequent sampling of SI would provide a more accurate follow-up, with clinical benefit. The comparison of the SI obtained from standard 10-20 electrodes and 2 bipolar EEG channel subsets in aEEG or between the 10-20 and simultaneous wearable recordings, demonstrated that the new method provides an accurate SI quantification. Conclusions: A wearable EEG device with 2 bipolar channels simplifies the process of obtaining repeated SI quantification allowing a more accurate follow-up of spike activity in the clinical setting.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho D, Mendes T, Dias AI, Leal A. Interictal spike quantification in continuous spike-wave of sleep (CSWS): clinical usefulness of a wearable EEG device. Epilepsy Behav. 2020;104(Pt A):106902.pt_PT
dc.identifier.doi10.1016/j.yebeh.2020.106902pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13162
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1525505019308881?via%3Dihubpt_PT
dc.subjectAction potentialspt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdrenal cortex hormonespt_PT
dc.subjectAdultpt_PT
dc.subjectChildrenpt_PT
dc.subjectDiet, Ketogenicpt_PT
dc.subjectElectroencephalographypt_PT
dc.subjectEpilepsypt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectLongitudinal studiespt_PT
dc.subjectMalept_PT
dc.subjectSleeppt_PT
dc.subjectSyndromept_PT
dc.subjectYoung adultpt_PT
dc.subjectWearable electronic devicespt_PT
dc.subjectCSWSpt_PT
dc.titleInterictal spike quantification in continuous spike-wave of sleep (CSWS): clinical usefulness of a wearable EEG devicept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issuePt Apt_PT
oaire.citation.startPage106902pt_PT
oaire.citation.titleEpilepsy & behavior : E&Bpt_PT
oaire.citation.volume104pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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