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Blood count, endocrine, immunologic, renal, and hepatic markers in a case-control animal study of induced periodontitis in female rodents

2024-02Journal article Open access
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dc.contributor.authorEstarreja, João
dc.contributor.authorPimenta, Ana Clara
dc.contributor.authorBotelho, João
dc.contributor.authorVilares, Arminda Maria
dc.contributor.authorMendes, José João
dc.contributor.authorRocha, João
dc.contributor.authorPinto, Rui
dc.contributor.authorMateus, Vanessa
dc.contributor.authorMachado, Vanessa
dc.date.accessioned2024-04-03T10:54:54Z
dc.date.available2024-04-03T10:54:54Z
dc.date.issued2024-02
dc.descriptionH&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020.pt_PT
dc.description.abstractIntroduction: Periodontitis is a non-communicable chronic inflammatory disease with a systemic burden. Animal models of induced periodontitis help elucidate the mechanisms by which periodontal inflammation drives systemic effects. Studying this systemic involvement over longer follow-up periods may provide a strong foundation for future research on the association between diseases and periodontitis, particularly in female rats. Therefore, we aimed to compare blood, endocrine, immunologic, renal, and hepatic markers in a rat model of induced periodontitis in females with their control counterparts. Methods: Experimental periodontitis was induced in 20 female Wistar rats by the application and maintenance of silk ligatures on the upper molars. The rats were then assessed for macroscopical analysis, complete blood count, and biochemical, endocrine, and immunologic markers at 21, 28, 42, and 56 days. Results: Chronic periodontal inflammation was observed after 42 days of exposure to the ligatures. Additionally, it was also possible to notice significant systemic manifestations, such as the reduction of triiodothyronine and thyroxine levels, along with an increase in the expression of alkaline phosphatase, gamma-glutamyl transpeptidase, and lactate dehydrogenase. Discussion: The study's findings imply that certain changes can be underscored to highlight a reduced risk of conception. Notably, previous investigations have indicated that subfertile women exhibit lower levels of thyroid hormones and elevated lactate dehydrogenase expression. Despite the absence of preclinical data delineating a possible association between periodontitis and female infertility, the results of this study may prove to be a crucial contribution to both the scientific and medical fields.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEstarreja J, Pimenta AC, Botelho J, Vilares AM, Mendes JJ, Mateus V, et al. Blood count, endocrine, immunologic, renal, and hepatic markers in a case-control animal study of induced periodontitis in female rodents. Front Physiol. 2024;15:1327399.pt_PT
dc.identifier.doi10.3389/fphys.2024.1327399pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17246
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1327399/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDisease animal modelspt_PT
dc.subjectInflammationpt_PT
dc.subjectNon-clinical study in vivopt_PT
dc.subjectPeriodontitispt_PT
dc.subjectRodentspt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleBlood count, endocrine, immunologic, renal, and hepatic markers in a case-control animal study of induced periodontitis in female rodentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage1327399pt_PT
oaire.citation.titleFrontiers in Physiologypt_PT
oaire.citation.volume15pt_PT
person.familyNameEstarreja
person.familyNamePinho Mateus
person.givenNameJoão
person.givenNameVanessa Alexandra
person.identifier.ciencia-idEB19-EDA2-704B
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-8283-3174
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd16a20d0-ac73-4989-b83d-abeab53139f7
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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