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Descemet’s membrane endothelial keratoplasty for corneal endothelial failure secondary to three types of phakic intraocular lens: retrospective study

2023-03Journal article Open access
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dc.contributor.authorMoura-Coelho, Nuno
dc.contributor.authorCunha, João Paulo
dc.contributor.authorDias-Santos, Arnaldo
dc.contributor.authorDutra-Medeiros, Marco
dc.contributor.authorPapa-Vettorazzi, Renato
dc.contributor.authorManero, Felicidad
dc.contributor.authorGüell, José
dc.date.accessioned2023-04-20T10:30:40Z
dc.date.available2023-04-20T10:30:40Z
dc.date.issued2023-03
dc.description.abstractPurpose: To analyze the outcomes of Descemet's membrane endothelial keratoplasty (DMEK) for corneal endothelial failure secondary to phakic intraocular lens implantation (PIOL) at a reference center for corneal transplantation in Spain. Design: Retrospective, single-surgeon case series. Methods: Single-center analysis of patients who underwent DMEK for PIOL-related corneal decompensation between July 2011 and July 2020 with at least 6 months of follow-up postoperatively. The primary outcome was the final best-corrected visual acuity (BCVA, logMAR) compared to pre-DMEK BCVA. Secondary outcomes analyzed included post-DMEK refractive spherical equivalent, endothelial cell loss (%ECL), and graft failure. Results: Sixteen eyes (14 patients) underwent DMEK for PIOL-related corneal decompensation. The Mean (SD) time to PIOL explantation was 9.3 (5.0) years, and the median (P25-P75) time between PIOL explantation and DMEK surgery was 3 (2-4) months. Median pre-DMEK BCVA was 0.80 (1.08-0.60) logMAR. A statistically significant improvement in BCVA was observed 1 month after DMEK (p = 0.001), and the median final BCVA was 0.15 (0.0-0.35) logMAR (p = 0.002). The mean %ECL was 55.6 (18.7) % at 2-year follow-up and 61.7 (11.7) % in eyes with over 4 years of follow-up. Two eyes required re-bubbling (12.5%), one of which ended in primary graft failure (6.2%) and one eye had late endothelial graft failure (LEGF) at 4-year follow-up (1/15 grafts, 6.7%). Conclusion: In patients with PIOL-related corneal decompensation, DMEK leads to good and clinically significant refractive and visual outcomes in the medium-long term, with a good safety profile. Prospective studies are encouraged to ascertain whether these cases are at increased risk of accelerated endothelial cell loss and LEGF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoura-Coelho N, Cunha JP, Dias-Santos A, Dutra-Medeiros M, Papa-Vettorazzi R, Manero F, et al. Descemet’s membrane endothelial keratoplasty for corneal endothelial failure secondary to three types of phakic intraocular lens: retrospective study. Clin Ophthalmol. 2023;17:931-40.pt_PT
dc.identifier.doi10.2147/OPTH.S401387pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15913
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/descemets-membrane-endothelial-keratoplasty-for-corneal-endothelial-fa-peer-reviewed-fulltext-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectCorneal endothelial failurept_PT
dc.subjectDescemet membrane endothelial keratoplastypt_PT
dc.subjectEndothelial keratoplastypt_PT
dc.subjectPhakic intraocular lenspt_PT
dc.titleDescemet’s membrane endothelial keratoplasty for corneal endothelial failure secondary to three types of phakic intraocular lens: retrospective studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage940pt_PT
oaire.citation.startPage931pt_PT
oaire.citation.titleClinical Ophthalmologypt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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