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Risk factors for metabolic bone disease in Crohn's disease patients

2010-12Journal article Open access
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dc.contributor.authorCravo, Marília
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorSantos, Paula Moura dos
dc.contributor.authorBrito, Miguel
dc.contributor.authorFerreira, Paula
dc.contributor.authorFidalgo, Catarina
dc.contributor.authorTavares, Lourdes
dc.contributor.authorPereira, António Dias
dc.date.accessioned2014-01-02T15:50:50Z
dc.date.available2014-01-02T15:50:50Z
dc.date.issued2010-12
dc.description.abstractBackground: The aim was to evaluate the presence of metabolic bone disease (MBD) in patients with Crohn’s disease (CD) and to identify potential etiologic factors. Methods: The case–control study included 99 patients with CD and 56 controls with a similar age and gender distribution. Both groups had dual-energy x-ray absorptionmetry and a nutritional evaluation. Single nucleotide polymorphisms at the IL1, TNF-a, LTa, and IL-6 genes were analyzed in patients only. Statistical analysis was performed using SPSS software. Results: The prevalence of MBD was significantly higher in patients (P ¼ 0.006). CD patients with osteoporosis were older (P < 0.005), small bowel involvement and surgical resections were more frequent (P < 0.005), they more often exhibited a penetrating or stricturing phenotype (P < 0.05), duration of disease over 15 years (P < 0.005), and body mass index (BMI) under 18.5 kg/m2 (P < 0.01) were more often found. No association was found with steroid use. Patients with a Z-score < 2.0 more frequently had chronic active disease (P < 0.05). With regard to diet, low vitamin K intake was more frequent (P ¼ 0.03) and intake of total, monounsaturated, and polyunsaturated fat was higher in patients with Z-score < 2.0 (P < 0.05). With respect to genetics, carriage of the polymorphic allele for LTa252 A/G was associated with a higher risk of osteoporosis (P ¼ 0.02). Regression analysis showed that age over 40 years, chronic active disease, and previous colonic resections were independently associated with the risk of developing MBD. Conclusions: The prevalence of MBD was significantly higher in CD patients. Besides the usual risk factors, we observed that factors related to chronic active and long-lasting disease increased the risk of MBD.por
dc.identifier.citationCravo M, Guerreiro CS, dos Santos PM, Brito M, Ferreira P, Fidalgo C, et al. Risk factors for metabolic bone disease in Crohn's disease patients. Inflamm Bowel Dis. 2010;16(12):2117-24.por
dc.identifier.issn1536-4844
dc.identifier.urihttp://hdl.handle.net/10400.21/3050
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/ibd.21297/pdfpor
dc.subjectBody compositionpor
dc.subjectBody mass indexpor
dc.subjectBone densitypor
dc.subjectBone diseasespor
dc.subjectCase-control studiespor
dc.subjectCrohn diseasepor
dc.subjectInterleukin-1por
dc.subjectInterleukin-6por
dc.subjectRisk factorpor
dc.subjectTumor necrosis factor-alphapor
dc.titleRisk factors for metabolic bone disease in Crohn's disease patientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2124por
oaire.citation.startPage2117por
oaire.citation.titleInflammatory Bowel Diseasespor
oaire.citation.volume16por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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