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Towards a systematic use of effect biomarkers in population and occupational biomonitoring

2021-01Journal article Restricted access
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dc.contributor.authorZare Jeddi, Maryam
dc.contributor.authorHopf, Nancy B.
dc.contributor.authorViegas, Susana
dc.contributor.authorPrice, Anna Bal
dc.contributor.authorPaini, Alicia
dc.contributor.authorvan Thriel, Christoph
dc.contributor.authorBenfenati, Emilio
dc.contributor.authorNdaw, Sophie
dc.contributor.authorBessems, Jos
dc.contributor.authorBehnisch, Peter A.
dc.contributor.authorLeng, Gabriele
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorVerhagen, Hans
dc.contributor.authorCubadda, Francesco
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorAli, Imran
dc.contributor.authorDavid, Arthur
dc.contributor.authorMustieles, Vicente
dc.contributor.authorFernandez, Mariana F.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorPasanen-Kase, Robert
dc.date.accessioned2020-12-22T10:48:34Z
dc.date.available2020-12-22T10:48:34Z
dc.date.issued2021-01
dc.description.abstractEffect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations and highlight their potential in monitoring humans exposed to chemical mixtures. We also discuss the role of the adverse outcome pathway (AOP) framework and physiologically based kinetic and dynamic (PBK/D) modelling to strengthen the understanding of the biological mechanism of effect biomarkers, and in particular for use in regulatory risk assessments. An interdisciplinary network of experts from the European chapter of the International Society for Exposure Science (ISES Europe) and the Organization for Economic Co-operation and Development (OECD) Occupational Biomonitoring activity of Working Parties of Hazard and Exposure Assessment group worked together to map the conventional framework of biomarkers and provided recommendations for their systematic use. We summarized the key aspects of this work here and discussed these in three parts. Part I, we inventory available effect biomarkers and promising new biomarkers for the general population based on the H2020 Human Biomonitoring for Europe (HBM4EU) initiative. Part II, we provide an overview of AOP and PBK/D modelling use that improved the selection and interpretation of effect biomarkers. Part III, we describe the collected expertise from the OECD Occupational Biomonitoring subtask effect biomarkers in prioritizing relevant mode of actions (MoAs) and suitable effect biomarkers. Furthermore, we propose a tiered risk assessment approach for occupational biomonitoring. Several effect biomarkers, especially for use in occupational settings, are validated. They offer a direct assessment of the overall health risks associated with exposure to chemicals, chemical mixtures and their transformation products. Promising novel effect biomarkers are emerging for biomonitoring of the general population. Efforts are being dedicated to prioritizing molecular and biochemical effect biomarkers that can provide a causal link in exposure-health outcome associations. This mechanistic approach has great potential in improving human health risk assessment. New techniques such as in silico methods (e.g. QSAR, PBK/D modelling) as well as ‘omics data will aid this process. Our multidisciplinary review represents a starting point for enhancing the identification of effect biomarkers and their mechanistic pathways following the AOP framework. This may help in prioritizing the effect biomarker implementation as well as defining threshold limits for chemical mixtures in a more structured way. Several ex vivo biomarkers have been proposed to evaluate combined effects including genotoxicity and xeno-estrogenicity. There is a regulatory need to derive effect-based trigger values using the increasing mechanistic knowledge coming from the AOP framework to address adverse health effects due to exposure to chemical mixtures. Such a mechanistic strategy would reduce the fragmentation observed in different regulations. It could also stimulate a harmonized use of effect biomarkers in a more comparable way, in particular for risk assessments to chemical mixtures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJeddi MZ, Hopf NB, Viegas S, Price AB, Paini A, van Thriel C, et al. Towards a systematic use of effect biomarkers in population and occupational biomonitoring. Environ Int. 2021;146:106257.pt_PT
dc.identifier.doi10.1016/j.envint.2020.106257pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12506
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0160412020322121pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectExposure sciencept_PT
dc.subjectMixture assessmentpt_PT
dc.subjectAdverse outcome pathwayspt_PT
dc.subjectPhysiologically based pharmacokineticpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectRisk assessmentpt_PT
dc.titleTowards a systematic use of effect biomarkers in population and occupational biomonitoringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106257pt_PT
oaire.citation.titleEnvironment Internationalpt_PT
oaire.citation.volume146pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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