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Genotoxicity biomarkers in occupational to formaldehyde in pathology anatomy laboratories

2011-06Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2011-11-22T16:52:16Z
dc.date.available2011-11-22T16:52:16Z
dc.date.issued2011-06
dc.description.abstractFormaldehyde (FA) the most simple and reactive of all aldehydes, is a colorless, reactive and readily polymerizing gas at normal temperature. It has a pungent, suffocating odour that is recognized by most human subjects at concentrations below 1ppm. According to the Report on Carcinogens, FA ranks 25th in the overall U.S. chemical production with more than 11 billion pounds (5 million tons) produced each year. Is an important industrial compound that is used in the manufacture of synthetic resins and chemical compounds such as lubricants and adhesives. It has also applications as a disinfectant, preservative and is used in cosmetics. Estimates of the number of persons who are occupationally exposed to FA indicate that, at least at low levels, may occur in a wide variety of industries. The occupational settings with most extensive use of formaldehyde is in the production of resins and in anatomy and pathology laboratories. Several studies reported a carcinogenic effect in humans after inhalation of FA, in particular an increased risk for nasopharyngeal cancer. Nowadays, the International Agency for Research on Cancer (IARC) classifies FA as carcinogenic to humans (group 1), on the basis of sufficient evidence in humans and sufficient evidence in experimental animals. Manifold in vitro studies clearly indicated that FA is genotoxic. FA induced various genotoxic effects in proliferatin cultured mammalian cells. A variety of evidence suggests that the primary DNA alterations after FA exposure are DNA-protein crosslinks. Incomplete repair of DPX can lead to the formation of mutations.por
dc.identifier.citationLadeira C, Gomes MC, Brito M. Genotoxicity biomarkers in occupational to formaldehyde in pathology anatomy laboratories. In 21st Meeting of the European Association for Cancer Research, Oslo (Norway), 26th to 29th June 2011. Poster.por
dc.identifier.urihttp://hdl.handle.net/10400.21/470
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectAnatomia patológicapor
dc.subjectMeio laboratorialpor
dc.subjectSaúde ocupacionalpor
dc.subjectFormaldeídopor
dc.titleGenotoxicity biomarkers in occupational to formaldehyde in pathology anatomy laboratoriespor
dc.typeconference object
dspace.entity.typePublication
person.familyNameLadeira
person.familyNameBrito
person.givenNameCarina
person.givenNameMiguel
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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