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The impact of 25-hydroxyvitamin D and calcium on risk of age-related macular degeneration: a Mendelian randomization study

2024-07Journal article Embargoed access
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dc.contributor.authorDong, Xing-Xuan
dc.contributor.authorChen, Dong-Ling
dc.contributor.authorMiao, Yi-Fan
dc.contributor.authorLi, Dan-Lin
dc.contributor.authorKai, Jia-Yan
dc.contributor.authorHu, Dan-Ning
dc.contributor.authorZhang, Xiao-Feng
dc.contributor.authorLança, Carla
dc.contributor.authorAndrzej, Grzybowski
dc.contributor.authorPan, Chen-Wei
dc.date.accessioned2024-07-29T10:17:19Z
dc.date.embargo2026-07-29
dc.date.issued2024-07
dc.descriptionThis study was supported by the National Natural Science Foundation of China (82122059).pt_PT
dc.description.abstractBackground: The relationships between 25-hydroxyvitamin D [25(OH)D] and calcium and age-related macular degeneration (AMD) are unclear. Objectives: This study aimed to investigate the causal role of 25(OH)D concentrations, calcium concentrations, and dietary supplements use of vitamin D and calcium on the risk of AMD and its subtypes. Methods: Independent genetic variants associated with 25(OH)D and calcium concentrations were used as instrumental variables in published genome-wide association studies (GWASs) of European ancestry. The bidirectional 2-sample Mendelian randomization (MR) analyses were performed using summary-level data from the UK Biobank and FinnGen datasets. Sensitivity analyses were conducted to ensure the robustness of the MR results. The meta-analyses were conducted using fixed and random-effect models to provide comprehensive and reliable estimates. Results: A standard deviation increase in calcium concentrations was linked to a 14%, 17%, and 13% reduction in the likelihood of developing AMD (95% confidence interval [CI]: 0.77, 0.97), wet AMD (95% CI: 0.73, 0.95), and dry AMD (95% CI: 0.75, 1.00), respectively. No significant causal relationships were detected between genetically predicted 25(OH)D concentrations and AMD and its subtypes (all P > 0.05). The combined analyses showed that higher calcium concentrations were associated with a reduced risk of overall AMD, with an odds ratio of 0.89 (95% CI: 0.81, 0.98). Conclusions: This study supports the causal relationship between calcium concentrations and the risk of AMD and its subtypes, which may have important implications for the prevention, monitoring, and treatment of AMD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDong XX, Chen DL, Miao YF, Li DL, Kai JY, Lança C, et al. The impact of 25-hydroxyvitamin D and calcium on risk of age-related macular degeneration: a Mendelian randomization study. Am J Clin Nutr. 2024;120(3):727-36.pt_PT
dc.identifier.doi10.1016/j.ajcnut.2024.06.018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17599
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0002916524005902pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectAge-related macular degenerationpt_PT
dc.subjectMendelian randomizationpt_PT
dc.subjectCalciumpt_PT
dc.subjectVitamin Dpt_PT
dc.subjectHealth preventionpt_PT
dc.titleThe impact of 25-hydroxyvitamin D and calcium on risk of age-related macular degeneration: a Mendelian randomization studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage736pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage727pt_PT
oaire.citation.titleThe American Journal of Clinical Nutritionpt_PT
oaire.citation.volume120pt_PT
person.familyNameLança
person.givenNameCarla
person.identifier.ciencia-id601A-6412-BF2F
person.identifier.orcid0000-0001-9918-787X
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0320b455-ee19-4670-8bf2-10dce9de1bec
relation.isAuthorOfPublication.latestForDiscovery0320b455-ee19-4670-8bf2-10dce9de1bec

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