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A human biomonitoring (HBM) Global Registry Framework: further advancement of HBM research following the FAIR principles

2021-09Artigo científico Acesso aberto
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dc.contributor.authorZare Jeddi, Maryam
dc.contributor.authorVirgolino, Ana
dc.contributor.authorFantke, Peter
dc.contributor.authorHopf, Nancy B.
dc.contributor.authorGalea, Karen S.
dc.contributor.authorRemy, Sylvie
dc.contributor.authorViegas, Susana
dc.contributor.authorMustieles, Vicente
dc.contributor.authorFernandez, Mariana F.
dc.contributor.authorvon Goetz, Natalie
dc.contributor.authorVicente, Joana Lobo
dc.contributor.authorSlobodnik, Jaroslav
dc.contributor.authorRambaud, Loïc
dc.contributor.authorDenys, Sébastien
dc.contributor.authorSt-Amand, Annie
dc.contributor.authorNakayama, Shoji F.
dc.contributor.authorSantonen, Tiina
dc.contributor.authorBarouki, Robert
dc.contributor.authorPasanen-Kase, Robert
dc.contributor.authorMol, Hans G.J.
dc.contributor.authorVermeire, Theo
dc.contributor.authorJones, Kate
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorvan der Voet, Hilko
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorVerhagen, Hans
dc.contributor.authorCanova, Cristina
dc.contributor.authorvan Klaveren, Jacob
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorBessems, Jos
dc.date.accessioned2021-10-12T09:55:26Z
dc.date.available2021-10-12T09:55:26Z
dc.date.issued2021-09
dc.description.abstractData generated by the rapidly evolving human biomonitoring (HBM) programs are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonized open-access protocol templates from designing, undertaking an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable, and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that the implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonized and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonized protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase the FAIRness of the resulting (meta)data. It is also considered that the harmonization of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimized. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalized. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policymakers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) works along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring the first demonstration of the first essential functionalities within the development of the HBM GRF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZare Jeddi M, Virgolino A, Fantke P, Hopf N, Galea KS, Viegas S, et al. A human biomonitoring (HBM) Global Registry Framework: further advancement of HBM research following the FAIR principles. Int J Hyg Environ Health. 2021;238:113826.pt_PT
dc.identifier.doi10.1016/j.ijheh.2021.113826pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13861
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463921001413?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectData governancept_PT
dc.subjectData value chainpt_PT
dc.subjectHarmonisationpt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectRegistrypt_PT
dc.subjectRegulatory risk assessmentpt_PT
dc.subjectBiological monitoringpt_PT
dc.subjectEnvironmental healthpt_PT
dc.subjectFAIR principlespt_PT
dc.subjectMetadatapt_PT
dc.titleA human biomonitoring (HBM) Global Registry Framework: further advancement of HBM research following the FAIR principlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage113826pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume238pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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