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Drug-related glomerular phenotypes: a global pharmacovigilance perspective

2024-08Journal article Open access
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dc.contributor.authorBaptista, Alexandre
dc.contributor.authorMacedo, Ana M.
dc.contributor.authorMarreiros, Ana
dc.contributor.authorCoelho, André
dc.contributor.authorPerazella, Mark A.
dc.date.accessioned2024-09-02T11:29:24Z
dc.date.available2024-09-02T11:29:24Z
dc.date.issued2024-08
dc.description.abstractIntroduction: Adverse drug reactions are a significant problem in modern society, stemming from the increase in prescribed medications, over-the-counter drugs, and overall polypharmacy. Glomerular disorders are one of the frequently reported renal conditions associated with medication use. VigiBase is a significant tool for evaluating events associated with drug use, and, to the authors’ knowledge, no study has yet assessed this database to identify the primary medications associated with glomerular disorders. Materials and Methods: We collected data from VigiBase for 54 years and evaluated data based on global frequencies, disproportionality (IC025 values), nephrotoxic potential, and physiopathological mechanisms. Results: Over the evaluation period, 33.932.051 spontaneous notifications of adverse drug reactions reported in VigiBase were assessed, from which 106.775 notifications of drug-associated glomerular disorders were extracted. The isolated medications were classified as ‘potential nephrotoxins’ (47.0%), with 40% of the medications lacking scientific references to report any association with the development of glomerular disorders. Among the evaluated medications, Inotersen (IC025 of 8.3), Penicillamine (IC025 6.8), Bevacizumab (IC025 5.9) and Lenvatinib (IC025 5.4) were identified as having the strongest association with these glomerular disorders. For medications classified as ‘non-nephrotoxic’, a high disproportionality index was observed, suggesting drugs that might be considered as new potential nephrotoxins. Conclusions: Drug-induced glomerular disorders were significantly associated with medications that had no established nephrotoxic role but demonstrated a high disproportionality index in VigiBase. These newly alleged nephrotoxic drugs warrant further evaluation in dedicated studies to assess their true nephrotoxic potential.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBaptista A, Macedo AM, Marreiros A, Coelho A, Perazella MA. Drug-related glomerular phenotypes: a global pharmacovigilance perspective. J Clin Med. 2024;13(16):4869.pt_PT
dc.identifier.doi10.3390/jcm13164869pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17656
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/13/16/4869pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPharmacologypt_PT
dc.subjectPharmacovigilancept_PT
dc.subjectDrug therapypt_PT
dc.subjectDrug-related side effectspt_PT
dc.subjectDrug-related adverse reactionspt_PT
dc.subjectGlomerular diseasespt_PT
dc.titleDrug-related glomerular phenotypes: a global pharmacovigilance perspectivept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue16pt_PT
oaire.citation.startPage4869pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume13pt_PT
person.familyNameFerreira Ramos Coelho
person.givenNameAndré Filipe
person.identifier.ciencia-id291E-1AC6-86FA
person.identifier.orcid0000-0003-1872-8131
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione00e9fd8-697d-4e70-acd3-e5a5169360ed
relation.isAuthorOfPublication.latestForDiscoverye00e9fd8-697d-4e70-acd3-e5a5169360ed

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