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Laboratory biomarkers associated to death in the first three COVID-19 waves in Portugal

2023-06Journal article Open access
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dc.contributor.authorVon Rekowski, Cristiana
dc.contributor.authorFonseca, Tiago
dc.contributor.authorCalado, Cecília
dc.contributor.authorBento, Luís
dc.contributor.authorPinto, Iola
dc.contributor.authorAraújo, Rúben
dc.date.accessioned2024-03-22T19:30:38Z
dc.date.available2024-03-22T19:30:38Z
dc.date.issued2023-06
dc.description.abstractBesides the pandemic being over, new SARS-CoV-2 lineages, and sub-lineages, still pose risks to global health. Thus, in this preliminary study, to better understand the characteristics of COVID-19 patients and the effect of certain hematologic biomarkers on their outcome, we analyzed data from 337 patients admitted to the ICU of a single-center hospital in Lisbon, Portugal, in the first three waves of the pandemic. Most patients belonged to the second (40.4%) and third (41.2%) waves. The ones from the first wave were significantly older and relied more on respiratory techniques like invasive mechanic ventilation and extracorporeal membrane oxygenation. There were no significant differences between waves regarding mortality in the ICU. In general, non-survivors had worse laboratory results. Biomarkers significantly associated with death changed depending on the waves. Increased high-sensitivity cardiac troponin I results, and lower eosinophil counts were associated to death in all waves. In the second and third waves, the international normalized ratio, lymphocyte counts, and neutrophil counts were also associated to mortality. A higher risk of death was linked to increased myoglobin results in the first two waves, as well as increased creatine kinase results, and lower platelet counts in the third wave.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1109/ENBENG58165.2023.10175345pt_PT
dc.identifier.isbn9798350322576
dc.identifier.urihttp://hdl.handle.net/10400.21/17207
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)pt_PT
dc.relationFunding Information: This study is inserted in the project Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine (PREMO), supported by Fundação para Publisher Copyright: © 2023 IEEEpt_PT
dc.subjectCOVID-19pt_PT
dc.subjectWavespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectICUpt_PT
dc.subjectRisk of deathpt_PT
dc.titleLaboratory biomarkers associated to death in the first three COVID-19 waves in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameVon Rekowski
person.familyNameSoares da Fonseca
person.familyNameCalado
person.familyNameBento
person.familyNamePinto
person.familyNameAraújo
person.givenNameCristiana
person.givenNameTiago
person.givenNameCecília
person.givenNameLuís
person.givenNameIola
person.givenNameRúben Alexandre Dinis
person.identifier130332
person.identifierR-000-ME5
person.identifier.ciencia-idB515-D281-0750
person.identifier.ciencia-id9418-E320-3177
person.identifier.ciencia-idE711-FA12-4784
person.identifier.ciencia-id5715-2B2D-9ADC
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.orcid0009-0009-6843-1935
person.identifier.orcid0000-0002-5264-9755
person.identifier.orcid0000-0002-0260-003X
person.identifier.orcid0000-0002-2945-1441
person.identifier.orcid0000-0002-9369-6486
person.identifier.ridE-2102-2014
person.identifier.ridL-6623-2018
person.identifier.scopus-author-id6603163260
person.identifier.scopus-author-id34969436900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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