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Exposure assessment to toluene in a chemical industry: complementarity between air monitoring and biomonitoring data

2018-10Conference object Open access
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dc.contributor.authorBarros, Miguel
dc.contributor.authorViegas, Susana
dc.date.accessioned2018-11-15T18:10:30Z
dc.date.available2018-11-15T18:10:30Z
dc.date.issued2018-10
dc.description.abstractToluene is a substance commonly used in the chemical industry. It is a volatile organic chemical and workers exposure occurs frequently by inhalation. The major metabolic pathway of toluene metabolism in humans involves sidechain oxidation by the sequential action of cytochrome P-450, alcohol dehydrogenase and aldehyde dehydrogenase leading to benzoic acid which, upon conjugation with glycine, results in hippuric acid, the major urinary metabolite, has long been considered a biomarker of exposure. Toluene affects the central nervous system, eyes, skin, respiratory system, liver, and kidneys. Exposure to high levels of toluene during pregnancy has been shown to result in children with birth defects and to retard mental abilities and growth and there is evidence that exposure to toluene is associated with spontaneous abortion. The objective of this study was to evaluate the occupational exposure to toluene in workers in a chemical manufacturing industry of polymers, recognize the main factors influencing exposure and identify measures to prevent workers exposure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBarros M, Viegas S. Exposure assessment to toluene in a chemical industry: complementarity between air monitoring and biomonitoring data. In: ICOETox 2018 – 4th International Congress on Occupational & Environmental Toxicology, Matosinhos, October 24-26, 2018.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/9051
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://icoetox2018.com/_files/200000093-d30fdd4093/ICOETox_2018_Final%20Programme-2.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectChemical industrypt_PT
dc.subjectToluenept_PT
dc.subjectBiomonitoringpt_PT
dc.titleExposure assessment to toluene in a chemical industry: complementarity between air monitoring and biomonitoring datapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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