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Telomeres are shorter in Portuguese obese adults

2024-10Artigo científico Acesso aberto
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dc.contributor.authorDuarte, Catarina
dc.contributor.authorBraz, Maria Teresa
dc.contributor.authorMarques-Ramos, Ana
dc.contributor.authorSilva-Nunes, José
dc.contributor.authorVeiga, Luisa
dc.contributor.authorBrito, Miguel
dc.date.accessioned2024-11-18T16:38:39Z
dc.date.available2024-11-18T16:38:39Z
dc.date.issued2024-10
dc.descriptionThe H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020.pt_PT
dc.description.abstractObesity is a clinical condition characterized by an abnormal accumulation of adipose tissue with an increased risk of developing illnesses such as type 2 diabetes, cardiovascular disease, and cancer. In obesity, the secretion of proinflammatory adipokines contributes to oxidative stress that can lead to a decline in the length of telomeres. Telomeres are structures of repetitive sequences delimiting the chromosomes, that play a crucial role in maintaining their integrity and stability and, thus, their shortening is associated with cellular senescence and possible apoptosis. Although some studies indicate that obesity is associated with shorter telomeres, others contradict this data. Accordingly, our study aimed to determine whether obesity is associated with telomere shortening in Portuguese obese adults. For that, we collected buccal epithelial cells from 72 obese (Body Mass Index (BMI) greater than 30 kg / m2) and 74 norm-weight individuals (BMI between 18.5 kg / m2 and 24.99 kg / m2) and determined telomere length through Real-Time PCR. Results revealed that the relative telomere length of obese individuals is statistically significantly shorter than that of the control non-obese group. By comparing obese subgroups, it was possible to observe that in the female subgroup, the relative length of telomeres was shorter, in opposition to the male obese group, which indicates that the association between high BMI and shorter telomeres is genre-dependent. Furthermore, by studying the telomere length by age it was observed that there was no difference in the relative telomere length in obese under versus over 45 years old, demonstrating an age-independent association between obesity and telomere length. Accordingly, our results suggest that obesity is associated with telomeres shortening and that this could be used as a biomarker in obesity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDuarte C, Braz MT, Marques-Ramos A, Silva-Nunes J, Veiga L, Brito M. Telomeres are shorter in Portuguese obese adults. J Mind Med Sci. 2024;11(2):381-7.pt_PT
dc.identifier.doi10.22543/2392-7674.1483pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17929
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherValpopt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2392-7674/11/2/48pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectObesitypt_PT
dc.subjectTelomerespt_PT
dc.subjectRelative lengthpt_PT
dc.subjectBody mass indexpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.subjectPortugalpt_PT
dc.titleTelomeres are shorter in Portuguese obese adultspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage387pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage381pt_PT
oaire.citation.titleJournal of Mind and Medical Sciencespt_PT
oaire.citation.volume11pt_PT
person.familyNameMarques-Ramos
person.familyNameVeiga
person.familyNameBrito
person.givenNameAna
person.givenNameLuisa
person.givenNameMiguel
person.identifier.ciencia-id0617-3550-881E
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-2655-8806
person.identifier.orcid0000-0003-1153-8343
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridL-2730-2013
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id8318978600
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0b8d516d-bf23-4db0-8224-d33e28d309ac
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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