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Nutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptoms

2021-11Journal article Open access
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dc.contributor.authorSantos, I.
dc.contributor.authorMendes, Lino
dc.contributor.authorMansinho, H.
dc.contributor.authorSantos, Carla Adriana
dc.date.accessioned2021-11-15T09:45:52Z
dc.date.available2024-11-15T01:30:25Z
dc.date.issued2021-11
dc.description.abstractRationale & aims: Pancreatic cancer (PC) is the third most common type of gastrointestinal tract cancer in Europe and the fourth leading cause of death by cancer. Its initial stage is asymptomatic Therefore, the diagnosis tends to be late leading to locally advanced stages that presuppose late and debilitating symptoms, which consequently makes the Nutritional Status (NS) get worse. The weight loss (WL), malnutrition, and oncologic cachexia, which are quite prevalent in PC patients, reflect a poor prognosis. We aimed to track and evaluate the NS and Functional Status (FS) of PC patients (hospitalized patients – HP and Day Hospital patients – DHP) and associate NS with symptoms with nutritional impact and FS. Methods: Observational cohort study in PC patients from Garcia de Orta Hospital. NS was tracked and evaluated using Nutritional Risk Screening (NRS-2002) and Patient-Generated Subjective Global Assessment (PG-SGA). To assess FS we used the Eastern Cooperative Oncology Group (ECOG), Karnofsky Performance Scale Index (KPSI), and Handgrip Dynamometer (HGD). Results: 41 PC patients (30-HP and 11-DHP). 29 patients in stage IV of the tumor. 24 with a WL >10% in the last 6 months. 37 manifest symptoms with nutritional impact. 30 to 34 malnourished according to the GLIM criteria and PG-SGA, respectively. 11 in ECOG level 2 and corresponding KPSI, 10 in level 3, and 8 in level 4. 28 patients had a value of HGD below the 10th percentile. NRS-2002, PG-SGA and GLIM criteria were positively correlated with the symptoms (p < 0.01), % WL (p < 0.01) and ECOG (p < 0.01) and negatively correlated with HGS (p < 0.05 – NRS-2002; p < 0.01 – PG-SGA and GLIM criteria). Conclusions: PC patients manifest debilitating symptoms with nutritional impact, namely severe WL and anorexia, which in turn lead to deterioration of the NS and FS. It is an oncology population with high nutritional risk and a higher prevalence of malnutrition, associated with severe % WL and symptoms and a sharp decline in FS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos I, Mendes L, Mansinho H, Santos CA. Nutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptoms. Clin Nutr. 2021;40(11):5486-93.pt_PT
dc.identifier.doi10.1016/j.clnu.2021.09.019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13994
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0261561421004362pt_PT
dc.subjectPancreatic cancerpt_PT
dc.subjectMalnutritionpt_PT
dc.subjectMalnutrition GLIM criteriapt_PT
dc.subjectSymptomspt_PT
dc.subjectWeight losspt_PT
dc.subjectFunctional statuspt_PT
dc.titleNutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptomspt_PT
dc.title.alternativeEstado nutricional e funcional dos doentes com cancro pancreático e o impacto da sintomatologia adjacentept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5493pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage5486pt_PT
oaire.citation.titleClinical Nutritionpt_PT
oaire.citation.volume40pt_PT
person.familyNameMendes
person.givenNameLino
person.identifier.ciencia-id7213-B138-6343
person.identifier.orcid0000-0002-7237-6272
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9a2fab80-3846-4dc3-a073-fad137f4a38c
relation.isAuthorOfPublication.latestForDiscovery9a2fab80-3846-4dc3-a073-fad137f4a38c

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