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Clinical and public health implications of HIV-genetic diversity and drug resistance mutations in Angola: a systematic review

2021-03Journal article Restricted access
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dc.contributor.authorSebastião, Cruz S.
dc.contributor.authorMorais, Joana
dc.contributor.authorBrito, Miguel
dc.date.accessioned2020-12-08T15:52:47Z
dc.date.available2020-12-08T15:52:47Z
dc.date.issued2021-03
dc.description.abstractHIV-1 genetic diversity and drug resistance mutations (DRMs) remain a public health concern mainly in low- and middle-income countries. In this review, we estimated the HIV-1 molecular evolution over the past 40 years (1980-2019) in Angola to help guide affordable strategies for HIV-1 epidemic surveillance. We searched for studies written in English or Portuguese on HIV-1 diversity and DRMs carried out in Angola and published between 1980 and 2019. This review yielded eight studies describing a total of 493 samples. No HIV-1 Group N, O, and P were identified, whereas a ll non-B subtypes f rom Group M were identified. About 66% of HIV-1 subtypes were pure subtype and 34% recombinant strains. The frequency of recombinant strains increases from 1980 to 2019 (23.6%-41.4%, p<0.001). The subtypes C, F1, CRF02_AG, and the recombinant U/H were the most frequent. One DRM in the PIs was found (I54 M), 22 in the nucleoside reverse transcriptase inhibitors (NRTIs), and 18 in the non-nucleoside reverse transcriptase inhibitors (NNRTIs). The major DRM in the NRTIs was the M184V, whereas the G190A, K103N, and Y181C were the major DRMs in the NNRTIs. Over the past 40 years, the frequency of the DRM M184V (50-64.3%, p=0.363), G190A (17.2-46.2%, p=0.021), and K103N (34.5-42.3%, p=0.551) increased, while the frequency of Y181C (17.2-7.7%, p=0.289) decreased. The current review shows an increase in HIV-1 genetic complexity and DRMs in Angola. Our findings suggest the need to include PIs or integrase strand transfer inhibitors in the first-line antiretroviral therapy regimens in Angola.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSebastião CS, Morais J, Brito M. Clinical and public health implications of HIV-genetic diversity and drug resistance mutations in Angola: a systematic review. AIDS Rev. 2021;23(1):48-56.pt_PT
dc.identifier.doi10.24875/AIDSRev.20000057pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12423
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.aidsreviews.com/resumen.php?id=1547&indice=0&u=unppt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHIV-1pt_PT
dc.subjectGenetic diversitypt_PT
dc.subjectDrug resistance mutationpt_PT
dc.subjectAntiretroviral therapy failurept_PT
dc.subjectAngolapt_PT
dc.titleClinical and public health implications of HIV-genetic diversity and drug resistance mutations in Angola: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage56pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleAIDS reviewspt_PT
oaire.citation.volume23pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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