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Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy

2015-03-01Journal article Restricted access
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dc.contributor.authorZomorodian, A.
dc.contributor.authorGarcia, M. P.
dc.contributor.authorSilva, Maria Teresa Oliveira de Moura e
dc.contributor.authorFernandes, João C. S.
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorMontemor, Maria de Fátima
dc.date.accessioned2016-03-08T14:37:10Z
dc.date.available2016-03-08T14:37:10Z
dc.date.issued2015-03-01
dc.description.abstractIn this work a biofunctional composite coating architecture for controlled corrosion activity and enhanced cellular adhesion of AZ31 Mg alloys is proposed. The composite coating consists of a polycaprolactone (PCL) matrix modified with nanohydroxyapatite (HA) applied over a nanometric layer of polyetherimide (PEI). The protective properties of the coating were studied by electrochemical impedance spectroscopy (EIS), a non-disturbing technique, and the coating morphology was investigated by field emission scanning electron microscopy (FE-SEM). The results show that the composite coating protects the AZ31 substrate. The barrier properties of the coating can be optimized by changing the PCL concentration. The presence of nanohydroxyapatite particles influences the coating morphology and decreases the corrosion resistance. The biocompatibility was assessed by studying the response of osteoblastic cells on coated samples through resazurin assay, confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). The results show that the polycaprolactone to hydroxyapatite ratio affects the cell behavior and that the presence of hydroxyapatite induces high osteoblastic differentiation. (C) 2014 Elsevier B.V. All rights reserved.pt_PT
dc.identifier.citationZOMORODIAN, A.; [et al.] - Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy. Materials Science & Engineering C-Materials for Bilogical Applications. ISSN. 0928-4931. Vol. 48 (2015), pp. 434-443pt_PT
dc.identifier.doi10.1016/j.msec.2014.12.027pt_PT
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/10400.21/5803
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier Science BVpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S092849311400825Xpt_PT
dc.subjectBioresorbable alloypt_PT
dc.subjectCorrosionpt_PT
dc.subjectFunctional coatingpt_PT
dc.subjectCell adhesionpt_PT
dc.titleBiofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage443pt_PT
oaire.citation.startPage434pt_PT
oaire.citation.volume48pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT

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