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Human biomonitoring in health risk assessment in Europe: current practices and recommendations for the future

2019-06Artigo científico Acesso restrito
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorHeinälä, Milla
dc.contributor.authorBessems, Jos
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorVermeire, Theo
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorvan Engelen, Jacqueline
dc.contributor.authorBorges, Teresa
dc.contributor.authorRousselle, Christophe
dc.contributor.authorOugier, Eva
dc.contributor.authorAlvito, Paula
dc.contributor.authorMartins, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSilva, Maria João
dc.contributor.authorPronk, Anjoeka
dc.contributor.authorSchaddelee-Scholten, Bernice
dc.contributor.authorDel Carmen Gonzalez, Maria
dc.contributor.authorde Alba, Mercedes
dc.contributor.authorCastaño, Argelia
dc.contributor.authorViegas, Susana
dc.contributor.authorHumar-Juric, Tatjana
dc.contributor.authorKononenko, Lijana
dc.contributor.authorLampen, Alfonso
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorSchoeters, Greet
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2019-06-21T11:55:19Z
dc.date.available2019-06-21T11:55:19Z
dc.date.issued2019-06
dc.description.abstractHuman biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real-life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative frameworks on chemicals (e.g., environmental, occupational, food safety, etc). In occupational health, HBM has long traditions to control the exposures at workplaces. By providing accurate data on internal exposure, HBM data can improve human health risk assessment (RA) for both the general population and workers. Although the past few years have shown good examples of the use of HBM in the RA of chemicals, there is still quite some work to be done to improve its use in a regulatory RA. Under the scope of the European Human Biomonitoring Initiative (project HBM4EU, 2017-2021), the current study reviews the state-of-the-art of HBM use in chemicals RA with a special focus in Europe and attempts to identify hurdles and challenges faced by regulators. To gather information on the use of HBM, including the availability of guidance on how to use it in RA, the RA schemes applied by different European or international organizations were analyzed. Examples of such use were identified for a few selected groups of chemicals of concern for human health. In addition, we present the results of a survey, aimed at collecting information from national regulatory risk assessors on their day-to-day RA practices, the use of HBM data, and the obstacles and challenges related to their use. The results evidenced and explained some of the current obstacles of using HBM data in RA. These included the lack of HBM guidance values or biomonitoring equivalents (BEs), limited toxicokinetic information to support the interpretation of HBM data and, in the occupational health and safety (OSH) field, the lack of legal enforcement. Therefore, to support the integration of HBM in regulatory RA, we recommend, on one hand, the elaboration of an EU level guidance on the use of HBM in RA and, on the other hand, the continuation of research efforts to integrate HBM with new RA approaches using in vitro/in silico data and Adverse Outcome Pathways (AOPs).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLouro H, Heinälä M, Bessems J, Buekers J, Vermeire T, Viegas S, et al. Human biomonitoring in health risk assessment in Europe: current practices and recommendations for the future. Int J Hyg Environ Health. 2019;222(5):727-37.pt_PT
dc.identifier.doi10.1016/j.ijheh.2019.05.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10178
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Human Biomonitoring Initiative (project HBM4EU, 2017–2021)pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463919301543?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectChemicalspt_PT
dc.subjectInternal exposurept_PT
dc.subjectHBM4EUpt_PT
dc.titleHuman biomonitoring in health risk assessment in Europe: current practices and recommendations for the futurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage737pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage727pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume222pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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