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Advisor(s)
Abstract(s)
The CotA laccase-catalysed oxidation of the meta, para-disubstituted arylamine 2,4-diaminophenyldiamine delivers, under mild reaction conditions, a benzocarbazole derivative (1) (74% yield), a key structural motif of a diverse range of applications. This work extends the scope of aromatic frameworks obtained using these enzymes and represents a new efficient and clean method to construct in one step C-C and C-N bonds.
Description
Keywords
Active carbazole alkaloids Transition-Metal-Complexes Organic-Synthesis Fungal laccases Antimicrobial activity Biological evaluation Coupling reactions Bacillus-subtilis Domino reactions Green chemistry
Citation
SOUSA, Ana Catarina; [et al.] - An enzymatic route to a benzocarbazole framework using bacterial CotA laccase. Green Chemistry. ISSN. 1463-9262. Vol. 17, N.º 3 (2015), pp. 1429-1433
Publisher
ROYAL SOC CHEMISTRY