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Dengue virus among HIV-infected pregnant women attending antenatal care in Luanda, Angola: an emerging public health concern

2022-08Journal article Open access
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dc.contributor.authorSebastião, Cruz S.
dc.contributor.authorNeto, Zoraima
dc.contributor.authorJandondo, Domingos
dc.contributor.authorMirandela, Marinela
dc.contributor.authorMorais, Joana
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-09-08T14:44:47Z
dc.date.available2022-09-08T14:44:47Z
dc.date.issued2022-08
dc.description.abstractThe dissemination of the dengue virus (DENV) in endemic regions with HIV is a public health concern with greater importance when there is evidence of vertical transmission of DENV during pregnancy. Herein, we investigated DENV among HIV-infected pregnant women in Luanda, the capital city of Angola. This was part of a cross-sectional study carried out on 42 pregnant women newly diagnosed with HIV. A total of 36 plasma samples from the 42 HIV-positive pregnant women were screened for DENV using RT‐PCR and ELISA. None of the specimens tested positive for DENV by RT-PCR. Regarding seroprevalence, 94.4% of the samples were positive for IgG and 11.1% for IgM. Recent infection (IgG-/IgM+ or IgG+/IgM+) was detected in 11.1% of the samples and past infection (IgG+/IgM-) in 83.3%. The risk of recent infection was higher in pregnant women over 25 years of age [OR: 13.0 (95% CI: 1.14-148), p=0.039]. Our study showed laboratory evidence of a recent DENV infection among HIV-infected pregnant women attending antenatal care in Luanda. Our findings provide critical data regarding DENV infection among HIV-infected pregnant women in Luanda. Future studies involving a larger sample size of HIV-infected pregnant women are necessary to support ongoing public health programs to combat arboviruses in Angola.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSebastião CS, Neto Z, Jandondo D, Mirandela M, Morais J, Brito M. Dengue virus among HIV-infected pregnant women attending antenatal care in Luanda, Angola: an emerging public health concern. Sci Afr. 2022;17:e01356.pt_PT
dc.identifier.doi10.1016/j.sciaf.2022.e01356pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14957
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2468227622002630pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDengue viruspt_PT
dc.subjectHIV infectionpt_PT
dc.subjectSeroprevalencept_PT
dc.subjectPregnant womenpt_PT
dc.subjectAngolapt_PT
dc.subjectLuandapt_PT
dc.titleDengue virus among HIV-infected pregnant women attending antenatal care in Luanda, Angola: an emerging public health concernpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee01356pt_PT
oaire.citation.titleScientific Africanpt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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