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Exposure to chemical mixtures in occupational settings: a reality in oncology day services?

2017-04Book part Restricted access
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dc.contributor.authorViegas, Susana
dc.contributor.authorOliveira, Ana Cebola
dc.contributor.authorPádua, Mário
dc.date.accessioned2017-06-01T13:55:39Z
dc.date.available2017-06-01T13:55:39Z
dc.date.issued2017-04
dc.description.abstractAntineoplastic drugs are essential to cancer treatment. Its widespread use in hospitals leads to an increased probability of occupational exposure of the healthcare professionals that manipulate the drugs. The fact that chemotherapy involves administration of multiple drugs only amplifies the problem resulting in the possible occupational exposure to a misture of these chemicals.The aim of this study was to determine the surfaces contamination by antineoplastic drugs in one Oncology Day Service and understand if it promotes exposure to chemical mixtures. Selected workplaces surfaces were wipe-sampled. 5-Fluorouracil, Paclitaxel (TM) and Cyclophosphamide in the samples were simultaneously analyzed by HPLC-DAD. Of the 45 collected samples, 4.4% were not contaminated, 40% presented contamination by only one drug and 55.6% showed contamination by more than one drug. The study allows the recognition that workers are exposed to mixtures of drugs. Interactions between drugs can be a reality and this justifies further research to support a cumulative risk assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas S, Oliveira AC, Pádua M. Exposure to chemical mixtures in occupational settings: a reality in oncology day services. In: Arezes PM, Baptista JS, Barroso MP, Carneiro P, Cordeiro P, Melo RB, et al, editors. Occupational safety and hygiene V. London: Taylor & Francis; 2017. p. 231-4.pt_PT
dc.identifier.doi10.1201/9781315164809-43pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7131
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCRC Presspt_PT
dc.relation.publisherversionhttp://www.crcnetbase.com/doi/pdfplus/10.1201/9781315164809-43pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEnvironmental healthpt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAntineoplastic drugpt_PT
dc.subjectChemotherapypt_PT
dc.subjectHealthcare professionalpt_PT
dc.subjectOncologypt_PT
dc.titleExposure to chemical mixtures in occupational settings: a reality in oncology day services?pt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage234pt_PT
oaire.citation.startPage231pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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