Repository logo
 
Publication

Anti-inflammatory effect of erythropoietin in the TNBS-induced colitis

2017-02Journal article Restricted access
Simple item page
dc.contributor.authorMateus, Vanessa
dc.contributor.authorRocha, João
dc.contributor.authorAlves, Paula
dc.contributor.authorMota-Filipe, Helder
dc.contributor.authorSepodes, Bruno
dc.contributor.authorPinto, Rui Manuel Amaro
dc.date.accessioned2016-12-22T12:02:37Z
dc.date.available2016-12-22T12:02:37Z
dc.date.issued2017-02
dc.description.abstractErythropoietin is a potent stimulator of erythroid progenitor cells, which is able to inhibit NF-kB activation, due to its pleiotropic properties, thus promoting an anti-inflammatory effect. As inflammatory bowel disease is a chronic disease with reduced quality of life, and the current pharmacotherapy only induces or maintains the patient in remission, there is a crucial need of new pharmacological approaches. The main objective of this study was to evaluate the effect of erythropoietin in the TNBS-induced colitis model in mice with a normal intestinal flora. Mice with TNBS-induced colitis were treated with a daily dose of erythropoietin at 500 IU/kg bw/day and 1000 IU/Kg bw/day IP during 4 days. As to clinical symptoms/signs, erythropoietin attenuated the decreased body-weight and reduced diarrhoea and oedema of the anus registered in the non-treated mice group in a dose-dependent manner. The anti-inflammatory properties of erythropoietin in the TNBS-induced colitis were confirmed by suppression of pro-inflammatory mediators, such as TNF-α, IL-1β and MPO, as well as a significant increase in the anti-inflammatory cytokine, IL-10, was promoted. These treated mice also presented a reduction in haemoglobin faecal and ALP, suggesting a beneficial effect of erythropoietin in the haemorrhagic focus and destruction of the enterocyte associated with the colon injury induced by TNBS, respectively. The histopathological score was reduced after treatment with erythropoietin, decreasing the severity and extension of the colitis. Furthermore, renal and hepatic biomarkers, as well as haematocrit concentration, remained stabilized after treatment. In conclusion, erythropoietin reduces the inflammatory response associated with TNBS-induced colitis in mice.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto RM. Anti-inflammatory effect of erythropoietin in the TNBS-induced colitis. Basic Clin Pharmacol Toxicol. 2017;120(2):138-45.pt_PT
dc.identifier.doi10.1111/bcpt.12663pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/bcpt.12663/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectErythropoietinpt_PT
dc.subjectTNBS-induced colitispt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.titleAnti-inflammatory effect of erythropoietin in the TNBS-induced colitispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage145pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage138pt_PT
oaire.citation.titleBasic and Clinical Pharmacology and Toxicologypt_PT
oaire.citation.volume120pt_PT
person.familyNamePinho Mateus
person.givenNameVanessa Alexandra
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Anti-inflammatory effect of erythropoietin in the TNBS-induced colitis.pdf
Size:
627.81 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos