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How to deal with uncertainties regarding the occupational exposure to antineoplastic mixtures: additive effect should always be considered?

2016-04Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorVeiga, Ana Costa
dc.date.accessioned2016-06-29T16:21:38Z
dc.date.available2016-06-29T16:21:38Z
dc.date.issued2016-04
dc.description.abstractRisk assessment considerations - The concept that “safe levels of exposure” for humans can be identified for individual chemicals is central to the risk assessment of compounds with known toxicological profiles. Selection of agents for combination chemotherapy regimens involves minimize overlapping of mechanisms of action, antitumor activity and toxicity profile. Although the toxicological profile and mechanism of action of each individual drug is well characterized, the toxicological interactions between drugs are likely, but poorly established at occupational exposure context. The synergistic nature of interactions may help in understanding the adverse health effects observed in healthcare workers, where exposure situations are characterized by complex mixtures of chemical agents, and the levels of individual exposing agents are often not sufficiently high to explain the health complaints. However, if a substance is a genotoxic carcinogen, this would be the “lead effect”; normally, no OEL based on a NOEL would be derived and the level would be set so low that it would be unlikely that other effects would be expected. Aim of the study - Recently research project developed in Portuguese Hospitals characterize the occupational exposure to antineoplastic agents and the health effects related. The project aimed to assess exposure of the different risk groups that handle antineoplastic agents in the hospital setting, namely during preparation and administration of these drugs. Here it is presented and discussed the results in a study developed in two hospitals from Lisbon.pt_PT
dc.identifier.citationLadeira C, Viegas S, Costa-Veiga A. How to deal with uncertainties regarding the occupational exposure to antineoplastic mixtures: additive effect should always be considered? In: Topical Scientific Workshop – New Approach Methodologies in Regulatory Science, Helsinki (Finland), 19-20 April 2016.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6263
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://echa.europa.eu/documents/10162/22322016/13_viegas_en.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAntineoplastic mixturespt_PT
dc.subjectSafe levels of exposurept_PT
dc.subjectChemotherapypt_PT
dc.subjectHospitalpt_PT
dc.subjectPortugalpt_PT
dc.titleHow to deal with uncertainties regarding the occupational exposure to antineoplastic mixtures: additive effect should always be considered?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceHelsínquiapt_PT
person.familyNameLadeira
person.familyNameViegas
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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