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Cytotoxicity assessment of nanoplastics and plasticizers exposure in in vitro lung cell culture systems: a systematic review

2022-07Journal article Open access
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dc.contributor.authorClérigo, Fabiana
dc.contributor.authorFerreira, Sandra
dc.contributor.authorLadeira, Carina
dc.contributor.authorMarques-Ramos, Ana
dc.contributor.authorAlmeida-Silva, M.
dc.contributor.authorMendes, L. A.
dc.date.accessioned2022-07-20T12:21:09Z
dc.date.available2022-07-20T12:21:09Z
dc.date.issued2022-07
dc.descriptionProjeto PLASCOGEN (IPL/2021/PLASCOGEN_ESTeSL).pt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractEmerging contaminants such as nanoplastics (NPs), as well as manufacturing by-products such as plasticizers, have gained global attention and concern due to their limited biodegradability and their potential impact on human health, in particular the effects on respiratory tissue. In parallel, in vitro cell culture techniques are key to the assessment and characterization of toxic effects and cellular mechanisms in different types of tissues and should provide relevant information to understand the hazardous potential of these emergent contaminants. This systematic review presents the main results of the current knowledge of the effects of NPs and plasticizers on lung cells, as assessed with the use of in vitro cell culture techniques. From the selected studies (n = 10), following the PRISMA approach, it was observed that cell viability was the most frequently assessed endpoint and that most studies focused on epithelial cells and exposures to polystyrene (PS). It was observed that exposure to NPs or plasticizers induces cytotoxicity in a dose-dependent manner, regardless of the size of the NPs. Furthermore, there is evidence that the characteristics of NPs can affect the toxic response by promoting the association with other organic compounds. As such, further in vitro studies focusing on the combination of NPs with plasticizers will be essential for the understanding of the mechanisms of NPs toxicity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClérigo F, Ferreira S, Ladeira C, Marques-Ramos A, Almeida-Silva M, Mendes LA. Cytotoxicity assessment of nanoplastics and plasticizers exposure in in vitro lung cell culture systems: a systematic review. Toxics. 2022;10(7):402.pt_PT
dc.identifier.doi10.3390/toxics10070402pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14856
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProjeto PLASCOGEN (IPL/2021/PLASCOGEN_ESTeSL)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/7/402pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectIn vitropt_PT
dc.subjectLung cellspt_PT
dc.subjectNanoplasticspt_PT
dc.subjectPlasticizerspt_PT
dc.subjectIPL/2021/PLASCOGEN_ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleCytotoxicity assessment of nanoplastics and plasticizers exposure in in vitro lung cell culture systems: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPage402pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
person.familyNameLadeira
person.familyNameMarques-Ramos
person.familyNameAlmeida-Silva
person.familyNameLima da Gama Mendes
person.givenNameCarina
person.givenNameAna
person.givenNameMarina
person.givenNameLuís André
person.identifier144237
person.identifieryJVZjbEAAAAJ&hl
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id0617-3550-881E
person.identifier.ciencia-id061F-0208-E861
person.identifier.ciencia-id0B1C-EC40-5E49
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-2655-8806
person.identifier.orcid0000-0002-4190-2727
person.identifier.orcid0000-0002-4573-8290
person.identifier.ridJ-2572-2012
person.identifier.ridB-3237-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id36866069400
person.identifier.scopus-author-id56900723200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication0b8d516d-bf23-4db0-8224-d33e28d309ac
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