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Advisor(s)
Abstract(s)
Sickle cell anemia (SCA) is caused by the presence of the sickle cell allele-HBB*S, in homozygosity. In sub-Saharan Africa, HBB*S typically reaches high frequencies, especially in regions where malaria is endemic. Epidemiologic evidence indicates that the burden of SCA, which currently represents a dramatic public health concern in sub-Saharan Africa, will predictably increase in the future. In this sense, the determination of prevalence, as well as markers of disease severity, are necessary so that the Ministry of Health can develop correct programs to manage the disease. The aim of the study: The objective of this work was to screen by direct sequencing of the HBB gene in a sample of newborns from Bengo, Angola. Moreover, we aim to identify common haplotypes of SCA by Multiplex SNaPshot system.
Description
Keywords
Public health Sickle cell anemia Infant Hemoglobinopathies Angola Província do Bengo
Citation
Tchonhi C, Borges E, Amorim A, Prata MJ, Brito M. Newborn screening of hemoglobinopathies in Bengo, Angola. In: International Conference Erythropoiesis Control and Ineffective Erythropoiesis: from bench to bedside, Budapest (Hungary), March 15-17, 2019.